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. 2018 Oct;188(10):2155–2163. doi: 10.1016/j.ajpath.2018.07.003

Figure 4.

Figure 4

Prx1-Wnt-GFP reporter activity in frontal bone defect healing. A and B: Micro–computed tomography reconstruction of frontal bone defect, in a top-down view with high magnification. Boxed area in A is shown at higher magnification in B. Dashed circle represents original bone defect. C: Prx1-Wnt-GFP reporter activity within the intact sagittal suture. Sagittal suture shown in coronal cross section, with parietal bone edges demarcated by dashed white lines. Boxed area is show at higher magnification in D. D: High-magnification image. D and E: Arrowhead (D) indicates representative reporter activity of Prx1-Wnt-GFP at the calvarial defect edge, before injury and at days (D) 3, 7, 14, and 21 after injury (E). The bone defect edge/bony margins are demarcated by dashed white lines. Scale bars: 100 μm (C and D); 50 μm (E). n, nasal bone; p, parietal bone.