Table 1.

Comparing DEFUSE-3, DAWN, and case report selection criteria

Study	Lesion	Time after symptom onset	Selection criteria	Infarct volume assessment
DAWN	Proximal MCA or internal ICA	6–24 h	Group A: <80 years, NIHSS 0–42, infarct <21 mL Group B: <80 years, NIHSS >10, infarct <31 mL Group C: <80 years, NIHSS >20, infract 31–51 mL	(1) Diffusion-weighted MRI at 24 h, followed by FLAIR or T2 MRI (2) Noncontrast CT or perfusion CT
DEFUSE-3	Proximal MCA or internal ICA	6–16 h	Infarct <70 mL, ratio of volume of ischemic tissue: infarct volume of 1.8, penumbra volume of >15 mL	(1) Diffusion-weighted MRI and MR perfusion scan (2) Perfusion CT
Case report	Proximal MCA	37.5 h	Worsening NIHSS score from 5 to 9 at ˜35 h, stable diffusion deficit with an infarct volume of 5.4 cm2	Diffusion-weighted MRI at 15 h followed by susceptibility-weighted MRI at 34 h