Skip to main content
. 2018 Sep 4;10(10):e9155. doi: 10.15252/emmm.201809155

Figure EV1. Small‐molecule drug screen in C. elegans identifies compounds relevant for CCM.

Figure EV1

  • A
    kri‐1 mutant worms treated with control L4440 RNAi and with DMSO are viable. Shown is a representative picture of a control well from a 96‐well plate.
  • B
    Treatment of kri‐1 mutants with ccm‐3 RNAi causes synthetic lethality. Incubation of this strain with DMSO (control) has no further effect on the synthetic lethality.
  • C
    Incubation of the ccm‐3 RNAi‐treated kri‐1 mutants with the phospholipase C inhibitor ET‐18‐OCH3 results in a mild rescue, as seen by the presence of a few worms.
  • D
    Incubation of the ccm‐3 RNAi‐treated kri‐1 mutants with the GSK‐3/PI3K/Akt/mTOR inhibitor TWS119 strongly rescues synthetic as indicated by the high number of worms.
Data information: All scale bars are 1 mm.