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Schematic representation of the NLRP3 inflammasome pathway which requires two signals: (i) a priming signal which activates NF‐kB, subsequently promoting the transcription of NLRP3 and pro‐IL‐1β, and (ii) an activation signal which facilitates the oligomerization of NLRP3, ASC, and procaspase‐1, resulting in the activation of NLRP3 inflammasome and secretion of mature IL‐1β and IL‐18.
