. 2018 Aug 14;9(38):7447–7454. doi: 10.1039/c8sc02371a

Table 2. Reduction of 4-phenyl-2-butanone using TbADH and Rh-based NADPH regeneration catalysts ^a .

Entry	Regeneration catalyst	Conversion (%)
1	—	0
2	[Cp*Rh(5M-C37L1)]²⁺	67
3	[Cp*Rh(H-L1)Cl]Cl	57
4	[Cp*Rh(5M-C37L2)]²⁺	71
5	[Cp*Rh(H-L2)Cl]Cl	58

^aCatalysis conditions: 4-phenyl-2-butanone (5 mM), NADP⁺ (0.5 mM), sodium formate (500 mM), Rh catalyst (25 μM), WT TbADH (1.5 μM) in buffer (sodium phosphate, 100 mM, pH 7) at 50 °C. Conversion and enantioselectivities were determined after 24 h by chiral HPLC, using a CHIRALCEL OD column. Conversion are presented as averages of triplicate runs, and standard deviations were <1%. Enantioselectivities were >99% ee in favour of the (S)-enantiomer, in all cases.

Table 2. Reduction of 4-phenyl-2-butanone using TbADH and Rh-based NADPH regeneration catalysts a .

Table 2. Reduction of 4-phenyl-2-butanone using TbADH and Rh-based NADPH regeneration catalysts ^a .