Table 1.
Genetic variants associated with NHCRC after meta-analyses of at least three independent datasets (primary meta-analyses)
| Gene | SNPs | Chr | Allelesa | Datasets | Cases | Controls | OR | CI-U | CI-L | P | FDR | Venice criteria | Level of evidence |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMP2 | rs961253 | 20 | C-A | 23 | 40507 | 40740 | 1.121 | 1.098 | 1.144 | 7.77E−27 | 7.15E−25 | AAA | High |
| CASC8 | rs10505477 | 8 | T-C | 13 | 12933 | 13259 | 0.856 | 0.828 | 0.886 | 9.27E−19 | 2.84E−17 | AAA | High |
| BMP4 | rs4444235 | 14 | T-C | 27 | 39030 | 39934 | 1.083 | 1.061 | 1.105 | 8.24E−15 | 1.89E−13 | AAA | High |
| SMAD7 | rs12953717 | 18 | C-T | 9 | 10782 | 10011 | 1.163 | 1.118 | 1.209 | 4.93E−14 | 8.00E−13 | AAA | High |
| CCAT2 | rs6983267 | 8 | G-T | 26 | 33098 | 30415 | 0.845 | 0.807 | 0.884 | 3.35E−13 | 3.86E−12 | AAA | High |
| TGF-β1 | rs1800469 | 19 | C-T | 21 | 17404 | 36234 | 0.911 | 0.887 | 0.936 | 1.59E−11 | 1.62E−10 | AAA | High |
| LOC105376400 | rs10795668 | 10 | G-A | 8 | 5744 | 5481 | 0.837 | 0.791 | 0.886 | 8.43E−10 | 5.27E−09 | AAA | High |
| GREM1-SCG5 | rs4779584 | 15 | C-T | 16 | 25151 | 24548 | 1.154 | 1.093 | 1.217 | 1.69E−07 | 8.62E−07 | AAA | High |
| ADIPOQ | rs2241766 | 3 | T-G | 7 | 2400 | 2972 | 1.216 | 1.115 | 1.326 | 9.33E−06 | 3.07E−05 | AAA | High |
| miR-27a | rs895819 | 19 | T-C | 5 | 1562 | 1852 | 1.192 | 1.076 | 1.320 | 0.001 | 0.002 | AAA | High |
| ADIPOR1 | rs1342387 | 1 | G-A | 5 | 1843 | 2563 | 0.824 | 0.755 | 0.900 | 1.82E−05 | 5.76E−05 | ABA | Intermediate |
| ICAM1 | rs5498 469 | 19 | A-G | 3 | 358 | 335 | 0.740 | 0.595 | 0.920 | 0.007 | 0.012 | BAA | Intermediate |
| PARP-1 | rs1136410 | 1 | T-C | 3 | 808 | 1849 | 1.181 | 1.043 | 1.337 | 0.009 | 0.015 | ABA | Intermediate |
| RHPN2 | rs10411210 | 19 | C-T | 15 | 22299 | 23280 | 0.881 | 0.844 | 0.919 | 6.12E−09 | 4.69E−08 | ABC | Low |
| SMAD7 | rs4464148 | 18 | T-C | 8 | 9736 | 8573 | 1.142 | 1.091 | 1.196 | 1.62E−08 | 1.15E−07 | AAC | Low |
| SMAD7 | rs4939827 | 18 | T-C | 17 | 16336 | 15443 | 0.859 | 0.813 | 0.908 | 5.94E−08 | 3.42E−07 | ACA | Low |
| CDH1 | rs9929218 | 16 | G-A | 17 | 22459 | 24079 | 0.930 | 0.903 | 0.958 | 1.51E−06 | 5.80E−06 | AAC | Low |
| COLCA1 | rs3802842 | 11 | A-C | 18 | 18043 | 17876 | 1.149 | 1.086 | 1.216 | 1.62E−06 | 5.97E−06 | ACC | Low |
| NA | rs719725 | 9 | A-C | 14 | 11820 | 13119 | 0.934 | 0.900 | 0.968 | 2.17E−04 | 5.56E−04 | AAC | Low |
| MLH1 | rs63750447 | 3 | T-A | 6 | 1427 | 1491 | 2.449 | 1.426 | 4.205 | 0.001 | 0.002 | CCC | Low |
| XPG | rs17655 | 13 | G-C | 8 | 4752 | 5648 | 1.101 | 1.036 | 1.170 | 0.002 | 0.004 | AAC | Low |
| NAT2 | rs1801280 | 8 | T-C | 3 | 2066 | 2581 | 0.876 | 0.807 | 0.952 | 0.002 | 0.004 | AAC | Low |
| NA | rs11568820 | 12 | G-A | 5 | 4278 | 4693 | 1.112 | 1.036 | 1.194 | 0.003 | 0.006 | AAC | Low |
| VDR | rs1544410 | 12 | G-A | 14 | 10404 | 11213 | 0.768 | 0.633 | 0.930 | 0.007 | 0.012 | ACC | Low |
| CCND1 | rs9344 | 11 | G-A | 21 | 4757 | 6680 | 1.119 | 1.026 | 1.220 | 0.011 | 0.017 | ACC | Low |
| CDH1 | rs16260 | 16 | C-A | 8 | 6062 | 7045 | 0.934 | 0.884 | 0.988 | 0.016 | 0.023 | AAC | Low |
| EGF | rs4444903 | 4 | G-A | 8 | 1234 | 1377 | 0.819 | 0.692 | 0.969 | 0.020 | 0.027 | ACC | Low |
| GREM1 | rs16969681 | 15 | C-T | 6 | 7300 | 9039 | 1.157 | 1.022 | 1.311 | 0.021 | 0.028 | ACA | Low |
| MTRR | rs1801394 | 5 | A-G | 19 | 8409 | 11893 | 1.046 | 1.004 | 1.089 | 0.030 | 0.036 | ABC | Low |
| NQO1 | rs1800566 | 16 | C-T | 13 | 6016 | 6905 | 1.142 | 1.013 | 1.288 | 0.030 | 0.036 | ACC | Low |
| MMP9 | rs3918242 | 20 | C-T | 5 | 829 | 1096 | 0.803 | 0.657 | 0.980 | 0.031 | 0.037 | BAC | Low |
| ERCC1 | rs11615 | 19 | C-T | 5 | 982 | 1251 | 1.147 | 1.011 | 1.302 | 0.033 | 0.037 | AAC | Low |
| APC | rs459552 | 5 | A-T | 13 | 9440 | 10200 | 0.950 | 0.905 | 0.997 | 0.037 | 0.041 | AAC | Low |
| CYP1A1 | rs1048943 | 15 | A-G | 13 | 3509 | 3960 | 1.287 | 1.011 | 1.637 | 0.040 | 0.043 | ACA | Low |
| GH1 | rs2665802 | 17 | T-A | 3 | 2740 | 3198 | 0.929 | 0.863 | 0.999 | 0.046 | 0.047 | AAC | Low |
| RETN | rs1862513 | 19 | C-G | 3 | 1013 | 1049 | 1.145 | 1.000 | 1.311 | 0.050 | 0.050 | ABC | Low |
Chr chromosome, FDR false discovery rate
aMajor alleles-minor alleles; Venice criteria: A (high), B (moderate), C (weak) credibility for three parameters (amount of evidence, heterogeneity and bias; see text and Additional file 1 for more details); level of evidence: overall level of summary evidence according to the Venice criteria