Table 3.
Mean absolute reduction and percentage change in PANSS in meta-analysis of randomized controlled trials (RCTs) of clozapine in treatment-resistant schizophrenia according to trial duration (table adapted from Siskind et al.54).
| Trial duration |
|||
|---|---|---|---|
| Short-term trials (<3 months) |
Long-term trials (>3 months) |
Any duration | |
| Mean absolute reduction in PANSS (95% CI) | 19.4 (19.0–20.9) | 24.0 (19.4–22.8) | 22.0 (20.9–13.1) |
| Mean % change in PANSS (95% CI) | 24.3 (23.1–25.5) | 20.9 (19.1–22.7) | 25.8 (24.7–26.9) |
CI, confidence interval; PANSS, Positive and Negative Syndrome Scale.