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. 2018 Aug 12;243(12):995–1003. doi: 10.1177/1535370218794128

Figure 1.

Figure 1.

Survival percentage, pulmonary arterial pressure, and right ventricular hypertrophy index (RVHI) in rats during 35 days after first monocrotaline (MCT) injection. (a) Experimental protocol: rats received a single intraperitoneal injection of 40 mg/kg MCT (SI group), twice injections of 20 mg/kg MCT (TI group), or normal saline (ctrl). (b) Kaplan-Meier survival curves showed that rats had a significantly higher survival percentage in the TI group than in the SI group (log-rank test, P < 0.01). (c) Representative waveforms of pulmonary arterial pressure in rats, showing continued movement of catheter when inserted into the pulmonary artery through right ventricle. Hemodynamic data were obtained by right cardiac catheterization. (d) Changes of mean pulmonary arterial pressure (mPAP) after injection of MCT. (e) Changes of RVHI during the progression of pulmonary arterial pressure on days 7, 14, 21, 28, and 35 after the first MCT injection. *P < 0.05 vs. ctrl of the corresponding day; #P < 0.05 vs. the SI group.