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. 2018 Sep 27;5:977–987. doi: 10.1016/j.toxrep.2018.09.004

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© 2018 Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Methylene blue staining of aberrant crypt foci (ACF) formation in the control and treated rats. (x40). (a) Topographical view of normal crypts in control rats. (c) Topographical view of ACF (arrows) with multiple crypts in the colon from rats exposed with 1, 2-dimethylhydrazine (DMH) carcinogen. (c) Topographical view of normal crypts from rats supplemented with orientin alone. (d) Topographical view of ACF (arrow) with 2 and 3 crypts in the colon from rats induced with DMH and treated with orientin (initiation). (E) Topographical view of ACF (arrow) with 2 crypts in the colon from rats under post initiation treatment with orientin (F) Topographical view of ACF (arrow) with no crypt in the colon from rats induced with DMH and treated with orientin for entire period.