Table 3.
Top 10 statistically significantly altered pathways in samples from responders to NET
| Ingenuity canonical pathways | -log (p value) | Number of genes and overlapping ratio (%) | z-score |
|---|---|---|---|
| Th1 Pathway | 22.3 | 40 (29.6) | 4.7 |
| iCOS-iCOSL signaling in T helper cells | 17.0 | 33 (26.8) | 4.3 |
| CD28 signaling in T helper cells | 16.9 | 34 (25.8) | 3.8 |
| PKCθ signaling in T lymphocytes | 14.2 | 31 (23.3) | 4.4 |
| Role of NFAT in regulation of the immune response | 12.9 | 34 (18.8) | 5.0 |
| B Cell receptor signaling | 7.9 | 28 (14.7) | 3.5 |
| Calcium-induced T lymphocyte apoptosis | 7.9 | 16 (24.2) | 4.0 |
| Tec kinase signaling | 7.8 | 26 (15.3) | 3.7 |
| PI3K signaling in B lymphocytes | 7.5 | 22 (16.9) | 4.1 |
| Neuroinflammation signaling pathway | 6.7 | 35 (11.3) | 2.7 |
Only top canonical pathways with predictive z-score ≥ 2 are presented, together with a p value. The overlapping ratio indicates the ratio of genes from the dataset that map to the pathway divided by the total number of genes that map to the same pathway