Fig. 1.

Survival plots of male and female wild-type (WT) and Shank3 transgenic (TG) mice in C57BL/6 J background. a Survival plot of male WT (black line) and Shank3 TG (blue line) mice from 3 to 12 weeks of age. Of the 123 Shank3 TG mice, 55 died before the age of 12 weeks, and 29 (53%) died before the age of 5 weeks. Two WT mice died during counting (Log-rank test, P < 0.0001). b Survival plot of female WT (black line) and Shank3 TG (red line) mice. Of the 51 Shank3 TG mice, 20 died before the age of 12 weeks, and 14 (70%) died before the age of 5 weeks. One WT mouse died during counting (Log-rank test, P < 0.0001). Numbers for the survival plots are provided in Additional file 2