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. 2018 Oct 8;36(42):6270–6281. doi: 10.1016/j.vaccine.2018.09.008

Table 1.

Summary of diarrhea and fecal VirHRV shedding after VirHRV challenge (PCD 1 to PCD 6).

Groupa N Diarrheab
Virus sheddingc
% of pigs Mean cumulative fecal scored Mean duration (days)e % of pigs Geometric mean of peak titer (FFU/ml)f Mean Duration (days)
Deficient HIFM 6 33.3 5.3 1.2 100 797.4** 2.5
Sufficient HIFM 6 0.0 3.8 NA 33.3 35.4* 1.5
a

Deficient HIFM; gnotobiotic (Gn) pigs transplanted with human infant fecal microbiota (HIFM) at 4 days of age (PTD 0) and fed protein deficient diet, Sufficient HIFM; Gn pigs transplanted with HIFM at 4 days of age and fed protein sufficient diet, All pigs were orally vaccinated twice with attenuated human rotavirus Wa strain (AttHRV) on post-transplantation day (PTD) 7 and 17, and challenged with virulent human rotavirus (VirHRV) on PTD 24.

b

Pigs with fecal score > 1 were considered as diarrheic. Fecal consistency was scored as follows: 0, normal; 1, pasty; 2, semi-liquid; and 3, liquid.

c

Determined by cell culture immunofluorescence assay and expressed as FFU/ml.

d

Mean of total of fecal scores from PCD 1 to PCD 6.

e

Mean of the total days with fecal score > 1.

f

Samples negative for HRV detection (<25) were assigned a titer of 12.5 for statistical analysis. Means in the same column with different asterisks differ significantly