Fig. 1.

Comparison of IL-37 levels between sJIA and HCs. a Expression of IL-37 mRNA in PBMCs from sJIA patients (n = 46), distributed according to disease activity (active, n = 23; inactive, n = 23), and HCs (n = 30) was determined by real-time PCR. b Plasma IL-37 levels in sJIA patients (n = 46), distributed according to disease activity (active, n = 23; inactive, n = 23), and HCs (n = 30) were measured by ELISA. Horizontal lines indicate median values. Differences between two groups were performed with Mann–Whitney U-test for nonparametric data. sJIA, systemic juvenile idiopathic arthritis; HCs, healthy controls; NS, not significant. **P < 0.001 by Student’s t test