Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 11;37:247. doi: 10.1186/s13046-018-0917-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 5 — GLI2/ARHGEF16 signaling promotes glioma progression. a-c Migration (a) and proliferation (b, c) in Control+sh-Control, GLI2A + sh-Control and GLI2A + sh-ARHGEF16 U87 cells were compared with the transwell migration, EdU and soft-agar colony formation assays, respectively. n = 3, *, P < 0.05; **, P < 0.01. d Growth curves of xenografts formed by the indicated U87 cells in nude mice. n = 5, **, P < 0.01. e Image of the indicated glioma xenografts. f Weight of the indicated glioma xenograft tumors. n = 5, **, P < 0.01. g Hematoxylin and eosin staining of tumor tissues samples from indicated groups and detection of GLI2, ARHGEF16, Ki76, and MMP9 protein levels by immunohistochemistry. h The decreased ARHGEF16 protein level in U87 GLI2A + sh-ARHGEF16 xenografts compared to U87 GLI2A + sh-Control xenografts