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. 2018 Oct 11;37:247. doi: 10.1186/s13046-018-0917-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — GLI2 inhibition suppresses glioma growth. a Growth curves of the indicated groups of U87 glioma xenografts treated with vehicle or GANT61. n = 5, **, P < 0.01. b Images of tumor-bearing mice. c Harvested glioma xenografts formed by indicated U87 glioma cell lines and treatment. d Weight of glioma xenograft tumors. n = 5, **, P < 0.01. e Validation of the decreased ARHGEF16 and GLI2 protein levels resulting from GANT61 treatment in Control, GANT61 and GLI2A, GANT61 groups compared to the vehicle groups, while FoxM1 was used as positive control. f Hematoxylin and eosin staining of tumor tissues samples from indicated groups and detection of GLI2, ARHGEF16, Ki76, and matrix MMP9 protein levels by immunohistochemistry