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. 2018 Sep 6;27(10):1495–1503. doi: 10.1177/0963689718795692

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Senescence in Lean- and MetS-MSCs. (A) Immunofluorescent staining of p16 and p21, showing significantly elevated p16 staining in MetS-MSCs, but not p21. (B) H2AX protein expression by Western-blot significantly increased in MetS-MSCs. (C) SA-ß-GAL activity was also higher in MetS-MSCs compared with Lean-MSCs.

*p < 0.05 vs. Lean-MSCs.

Lean-MSC: Lean diet mesenchymal stem cell; MetS-MSC: metabolic syndrome mesenchymal stem cell; SA-ß-GAL: senescence-associated β-galactosidase; H2AX: H2A Histone Family Member X; RFU: relative fluorescence unit; GAPDH: glyceraldehyde 3-phosphate dehydrogenase.