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MiR-27b inhibition and senescence. After inhibition of miR-27b in MetS-MSCs, the expression of p16 was significantly downregulated, whereas CDKN1A (p21) was not. MAPK3 was also downregulated after miR-27b inhibition.
#p < 0.05 vs. Lean-MSCs.
*p < 0.05 vs. MetS-MSCs+anti miR-NC.
Lean-MSC: Lean diet mesenchymal stem cell; MetS-MSC: metabolic syndrome mesenchymal stem cell; MAPK: mitogen-activated protein kinase.
