Table 2.

Plasma Cytokines Kinetics in Brain-Dead Patients.

	Baseline (n = 16)	Time point 2 (n = 15)	Time point 3 (n = 6)	P
TNF (pg/mL)	2.70 (0.99–4.76)	3.28 (0.99–6.59)	0.99 (0.99–5.95)	0.278
IL-1β (pg/mL)	5.39 (1.93–16.89)	7.11 (1.93–29.13)	6.48 (1.93–19.21)	0.012§
IFN- γ (pg/mL)	2.79 (1.6–6.06)	2.79 (1.6–6.06)	4.04 (0.47–8.57)	0.045*
IL-6 (pg/mL)	174.48 (104.9–692.51)	223.74 (142.79–2664.93)	395.77 (22.93–5594.31)	0.096
IL-8 (pg/mL)	80.30 (18.72–169.61)	68.24 (39.84–222.37)	90.71 (26.43–241.29)	0.391
IL-10 (pg/mL)	8.78 (3.62–16.49)	15.73 (5.49–23.98)	11.1 (1.17–15.23)	0.009§

^§Baseline and time point 2 are different. * P is non-significant in post-hoc analysis (P = 1.0).

Baseline refers to the first clinical examination consistent with BD (1.4 ± 1.3 h after study entry); time point 2 refers to the second clinical examination consistent with BD (7 ± 1.2 h after study entry); time point 3 refers to the time of organ retrieval (14.7 ± 2.1 h after study entry).