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. 2018 Oct 2;24:6989–7000. doi: 10.12659/MSM.910930

Figure 6.

Figure 6

The protein expression of metformin on AMPK-mTORC/PGC-1α signaling pathway in SD- NRVCs. (A) Western blot analysis was used to detect the related gene expression levels of the AMPK-mTORC/PGC-1α signaling pathway. Expression levels of NT-PGC-1α/PGC-1α, mTOR, and AMPK p-AMPK protein level after treatment with different doses of metformin. (B) The quantity of protein expression level of NT-PGC-1α/PGC-1α, and AMPK p-AMPK protein level after treatment with different doses of metformin. (C) The quantity of protein expression level of mTOR protein level after treatment with different doses of metformin. (D) The ratio of p-AMPK/AMPK protein level after being treated with different doses of metformin. Data are presented as mean ±SD from 3 independent experiments. ** P<0.05, compared with the Met (0.5 nM) group.