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Phylogenetic tree indicating evolutionary relationships of PERIOD orthologs across taxa. The nudibranch PERIOD proteins were most closely related to other molluscs but, unlike CLOCK and BMAL1, shared more recent common ancestry with arthropods than chordates, though with low bootstrap support for this relationship. The tree was rooted on NEURONAL NPAS DOMAIN PROTEIN (NPAS) from the oyster Crassostrea gigas (Perrigault and Tran, 2017).
