Table 3.
Multivariate analysis of the patients' dataset for PFS without (A) and including (B) imaging biomarkers. Harrel c-indexes of the models, which score their prognostic power, are 0.65 and 0.76, respectively. The two c-indexes are significantly different with a p value of 0.01.
| p value | HR | 95% CI for HR | ||
|---|---|---|---|---|
| Lower | Upper | |||
| (A) | ||||
| Gender (F vs M) | 0.713 | 1.191 | 0.469 | 3.026 |
| Age | 0.426 | 1.014 | 0.979 | 1.050 |
| Stage (III vs IV) | 0.160 | 1.894 | 0.777 | 4.617 |
| Tumor site (oropharynx vs others) | 0.902 | 0.953 | 0.445 | 2.042 |
| CHT (No vs Yes) | 0.176 | 0.489 | 0.173 | 1.378 |
|
| ||||
| (B) | ||||
| Age | 0.254 | 1.02E + 00 | 9.86E − 01 | 1.06E + 00 |
| Stage (III vs IV) | 0.440 | 1.43E + 00 | 5.77E − 01 | 3.55E + 00 |
| CHT (No vs Yes) | 0.012 | 2.03E − 01 | 5.84E − 02 | 7.06E − 01 |
| Run percentage | 0.176 | 1.97E − 01 | 1.87E − 02 | 2.07E + 00 |
| LILRE | <0.001 | 1.41E − 83 | 4.05E − 128 | 4.90E − 39 |
| Coarseness | 0.970 | 4.12E − 01 | 2.32E − 21 | 7.33E + 19 |
| Code similarity | 0.129 | 4.27E − 23 | 5.77E − 52 | 3.16E + 06 |