Supplementary Table 1.
Individual CpG sites associated with NAFLD (q<0.05) in circulating leukocytes. (N=64).
| Probe ID | p NAFLD | q NAFLD | NAFLD mean β | CL mean β | Difference (% points) | Gene symbol | UCSC RefGene Acession | Relation to gene region | Relation to CpG island |
|---|---|---|---|---|---|---|---|---|---|
| cg00150500 | 5.05E-08 | 0.003526 | 0.040611 | 0.026409 | 0.014201229 | HCFC1R1; THOC6 | NM_017885; NM_001002018; NM_001002017; NM_001142350; NM_024339 | Body; TSS1500 | Island |
| cg01693328 | 3.78E-06 | 0.037736 | 0.734933 | 0.689903 | 0.045030407 | S_Shelf | |||
| cg02013957 | 2.80E-07 | 0.008217 | 0.069828 | 0.108342 | −0.03851329 | CAGE1; RIOK1 | NM_205864; NM_031480; NM_001170693; NM_001170692 | TSS1500; Body | S_Shore |
| cg03511638 | 7.43E-06 | 0.04944 | 0.207524 | 0.192478 | 0.015045277 | FBXL15 | NM_024326; NM_024326 | 1st Exon; 5′UTR | Island |
| cg03615240 | 2.36E-06 | 0.029878 | 0.234903 | 0.217214 | 0.01768861 | Island | |||
| cg03753066 | 2.57E-06 | 0.029878 | 0.042778 | 0.033719 | 0.009058818 | PGPEP1 | NM_017712 | TSS200 | N_Shore |
| cg03956053 | 4.68E-06 | 0.040684 | 0.094807 | 0.069568 | 0.025238064 | Island | |||
| cg03992938 | 7.18E-06 | 0.04944 | 0.201834 | 0.1878 | 0.014034138 | CCDC13 | NM_144719; NM_144719 | 1st Exon; 5′UTR | Island |
| cg04160753 | 5.99E-06 | 0.046488 | 0.275213 | 0.255442 | 0.019770564 | C10orf91 | NM_173541 | TSS1500 | |
| cg04396550 | 3.68E-12 | 1.54E-06 | 0.037964 | 0.025583 | 0.012380549 | KCNQ3 | NM_004519 | TSS1500 | Island |
| cg04787602 | 2.61E-07 | 0.008217 | 0.161306 | 0.144232 | 0.017073828 | C1orf183 | NM_198926; NM_019099 | Body; TSS1500 | Island |
| cg04981696 | 5.54E-07 | 0.012898 | 0.559923 | 0.491968 | 0.067954905 | ABCC1 | NM_019862; NM_019898; NM_019899; NM_004996; NM_019900 | Body | S_Shore |
| cg05102190 | 7.38E-06 | 0.04944 | 0.292254 | 0.261536 | 0.030718122 | ZYX | NM_003461; NM_001010972 | TSS200 | Island |
| cg06706068 | 6.62E-06 | 0.04866 | 0.450319 | 0.399254 | 0.051064413 | RPUSD1 | NM_058192 | 3′UTR | N_Shore |
| cg07067744 | 6.97E-06 | 0.04944 | 0.920563 | 0.90232 | 0.018243335 | BRSK2 | NM_003957 | Body | |
| cg07112456 | 6.04E-07 | 0.013311 | 0.931972 | 0.912429 | 0.019543021 | LRWD1 | NM_152892 | Body | S_Shelf |
| cg07953400 | 1.74E-06 | 0.02696 | 0.054226 | 0.045265 | 0.008961501 | PIGQ | NM_004204; NM_148920 | TSS1500; TSS1500 | N_Shore |
| cg07956264 | 1.06E-07 | 0.006374 | 0.060192 | 0.042644 | 0.017547367 | GPATCH3 | NM_022078 | 1st Exon | Island |
| cg08013262 | 2.14E-06 | 0.028915 | 0.051125 | 0.040134 | 0.010991397 | INSR | NM_000208; NM_001079817 | Body | Island |
| cg09367046 | 6.48E-06 | 0.048457 | 0.078046 | 0.057973 | 0.020073316 | ANGEL1 | NM_015305 | TSS200 | Island |
| cg09826692 | 3.66E-07 | 0.009581 | 0.695734 | 0.717446 | −0.0217123 | Island | |||
| cg10077144 | 6.43E-06 | 0.048457 | 0.151084 | 0.136608 | 0.014476221 | Island | |||
| cg10178228 | 2.57E-06 | 0.029878 | 0.16383 | 0.11116 | 0.052670088 | FRMD4B | NM_015123 | TSS200 | S_Shore |
| cg10576516 | 2.94E-07 | 0.008217 | 0.046487 | 0.034138 | 0.01234886 | RECQL5; SAP30BP | NM_001003716; NM_013260; NM_001003715; NM_013260; NM_004259 | TSS200; 1st Exon; 5′UT | Island |
| cg12289509 | 9.38E-07 | 0.019426 | 0.12632 | 0.116298 | 0.010022888 | TUBE1 | NM_016262; NM_001033564 | Body; TSS200 | Island |
| cg12362980 | 3.73E-06 | 0.037736 | 0.890648 | 0.915371 | −0.02472296 | Island | |||
| cg13291296 | 1.94E-06 | 0.028151 | 0.928293 | 0.567811 | 0.360481701 | GPR125 | NM_145290 | Body | |
| cg13373361 | 9.74E-07 | 0.019426 | 0.972063 | 0.958036 | 0.014027139 | MYH16 | NR_002147 | Body | |
| cg13397649 | 2.39E-06 | 0.029878 | 0.184331 | 0.171045 | 0.013286234 | AFG3L2 | NM_006796 | 1st Exon | Island |
| cg13463639 | 1.14E-07 | 0.047685 | 0.795196 | 0.744952 | 0.050244062 | SIGIRR | NM_001135053; NM_021805 | TSS1500 | S_Shore |
| cg13920768 | 4.76E-06 | 0.040684 | 0.180692 | 0.16038 | 0.02031251 | PRDM12 | NM_021619 | 3′UTR | Island |
| cg14214745 | 1.61E-06 | 0.025892 | 0.030079 | 0.02396 | 0.006119444 | CRELD1 | NM_001077415; NM_001031717; NM_015513; NM_015513; NM_001077415; NM_001031717 | 1st Exon; 5′UTR | Island |
| cg14247318 | 2.91E-06 | 0.032137 | 0.06859 | 0.051255 | 0.017334521 | S_Shore | |||
| cg14451560 | 4.08E-06 | 0.038185 | 0.163369 | 0.130014 | 0.033355016 | ARRDC1 | NM_152285 | TSS1500 | N_Shore |
| cg15317837 | 4.86E-06 | 0.0407 | 0.082077 | 0.065888 | 0.016188353 | GTPBP4 | NM_012341 | TSS1500 | Island |
| cg15653194 | 1.99E-09 | 0.000271 | 0.077077 | 0.051633 | 0.025443482 | LFNG | NM_001166355; NM_002304; NM_001040168; NM_001040167 | Body; TSS200 | Island |
| cg16105594 | 1.46E-06 | 0.025002 | 0.222788 | 0.206881 | 0.015907317 | MEF2C | NM_001131005; NM_002397 | 5′UTR; TSS1500 | Island |
| cg16261091 | 5.26E-06 | 0.042403 | 0.871221 | 0.768176 | 0.103045403 | C17orf101; HEXDC | NM_175902; NM_173620; NM_024648 | Body; TSS1500 | N_Shore |
| cg16357287 | 1.96E-07 | 0.007527 | 0.033464 | 0.022286 | 0.011177644 | SEH1L | NM_001013437; NM_031216 | TSS1500 | N_Shore |
| cg16398128 | 1.66E-07 | 0.007527 | 0.038963 | 0.025503 | 0.01345955 | ZNF622 | NM_033414; NM_033414 | 5′UTR; 1st Exon | Island |
| cg16416718 | 4.04E-06 | 0.038185 | 0.168379 | 0.155538 | 0.012840944 | CAMTA1 | NM_015215 | TSS1500 | Island |
| cg16487280 | 1.11E-06 | 0.020289 | 0.163618 | 0.146336 | 0.017282797 | MYBL2 | NM_002466 | TSS1500 | Island |
| cg17162475 | 1.08E-06 | 0.020289 | 0.136101 | 0.120308 | 0.015793168 | C6orf150 | NM_138441 | TSS200 | Island |
| cg17176517 | 5.44E-06 | 0.042966 | 0.055192 | 0.043187 | 0.012004537 | SNX4 | NM_003794; NM_003794 | 5′UTR; 1st Exon | Island |
| cg18570553 | 3.67E-06 | 0.037736 | 0.144011 | 0.128948 | 0.015063351 | PRR15 | NM_175887 | TSS200 | N_Shore |
| cg18848688 | 1.42E-08 | 0.001192 | 0.143981 | 0.325489 | −0.18150742 | LIFR | NM_001127671; NM_002310 | TSS1500; 5′UTR | Island |
| cg19137662 | 1.98E-07 | 0.007527 | 0.045624 | 0.032493 | 0.013131109 | NOP56 | NM_006392; NR_031699; NR_027700; NR_003078 | Body; TSS200 | Island |
| cg19189310 | 1.49E-06 | 0.025002 | 0.201487 | 0.18607 | 0.015416665 | RPS10 | NM_001014 | 5′UTR | Island |
| cg21786114 | 2.28E-07 | 0.007946 | 0.516219 | 0.460762 | 0.055456681 | EHMT2 | NM_006709; NM_025256 | TSS1500 | N_Shore |
| cg22185268 | 3.99E-07 | 0.009831 | 0.026994 | 0.020076 | 0.006918145 | COMMD4 | NM_017828 | TSS200 | Island |
| cg22402398 | 2.50E-06 | 0.029878 | 0.939115 | 0.923689 | 0.015425828 | FGR | NM_001042747; NM_005248; NM_001042729 | TSS1500; 5′UTR | |
| cg22598233 | 3.16E-06 | 0.033997 | 0.069128 | 0.056446 | 0.012681401 | POLRMT | NM_005035 | TSS200 | Island |
| cg22721468 | 1.96E-06 | 0.028151 | 0.060214 | 0.04424 | 0.01597372 | SH3BP5L | NM_030645 | TSS1500 | Island |
| cg22746421 | 1.52E-07 | 0.007527 | 0.87434 | 0.852661 | 0.021678989 | ||||
| cg23224405 | 2.59E-09 | 0.000271 | 0.064945 | 0.045018 | 0.019927219 | DUSP16 | NM_030640; NM_030640 | 1st Exon; 5′UTR | Island |
| cg24199050 | 2.65E-06 | 0.029971 | 0.010376 | 0.006359 | 0.004017477 | GTSE1 | NM_016426; NR_024009 | TSS200 | Island |
| cg24239690 | 7.36E-06 | 0.04944 | 0.196241 | 0.181611 | 0.014630372 | FSCN1 | NM_003088 | Body | S_Shore |
| cg24689754 | 4.95E-06 | 0.0407 | 0.029538 | 0.020196 | 0.009341864 | C19orf62 | NM_001033549; NM_001033549; NM_014173; NM_014173 | 5′UTR; 1st Exon | |
| cg25295726 | 1.84E-09 | 0.000271 | 0.181557 | 0.162827 | 0.018730389 | FUT11 | NM_173540 | TSS200 | Island |
| cg25456633 | 4.20E-06 | 0.038224 | 0.897003 | 0.878185 | 0.018817636 | ||||
| cg25818813 | 4.10E-06 | 0.038185 | 0.064429 | 0.050092 | 0.014336947 | MERTK | NM_006343 | Body | Island |
| cg26105057 | 2.02E-06 | 0.028151 | 0.160883 | 0.126787 | 0.034095982 | PAN2 | NM_014871; NM_001166279; NM_001127460; NM_014871; NM_001166279 | 1st Exon; 5′UTR; TSS200 | Island |
| cg26309655 | 4.66E-06 | 0.040684 | 0.16828 | 0.148223 | 0.02005632 | TARS2 | NM_025150 | TSS200 | |
| cg12473838 | 4.88E-06 | 0.028795 | 0.040501 | 0.031202 | 0.009299747 | SSBP1 | NM_003143; NR_015392 | TSS200; Body | Island |
| cg26786980 | 6.79E-06 | 0.049042 | 0.220594 | 0.183155 | 0.037438788 | RARB | NM_016152; NM_016152; NM_000965; NM_000965 | 5′UTR; 1st Exon |