Supplementary Table 2.
Individual CpG sites associated with simple hepatic steatosis (q<0.05) in circulating leukocytes. (N=119).
| Probe ID | p Simple hepatic steatosis | q Simple hepatic steatosis | Simple hepatic steatosis mean β | CL mean β | Difference (% points) | Gene symbol | UCSC RefGene acession | Relation to gene region | Relation to CpG island |
|---|---|---|---|---|---|---|---|---|---|
| cg00150500 | 0.00000 | 0.00005 | 0.04354 | 0.02641 | 0.01713 | HCFC1R1; THOC6 | NM_017885; NM_001002018; NM_001002017; NM_001142350; NM_024339 | Body; TSS1500 | Island |
| cg00574958 | 0.00000 | 0.02625 | 0.13777 | 0.19441 | −0.05664 | CPT1A; CPT1A | NM_001876; NM_001031847 | 5′UTR | N_Shore |
| cg00639286 | 0.00001 | 0.03794 | 0.11783 | 0.09329 | 0.02454 | ATOX1 | NM_004045 | Body | Island |
| cg00932007 | 0.00000 | 0.02625 | 0.07328 | 0.04803 | 0.02525 | SERINC1; PKIB | NM_020755; NM_181794; NM_020755 | 1st Exon; TSS200; 5′UTR | Island |
| cg01067963 | 0.00001 | 0.02968 | 0.06460 | 0.04919 | 0.01541 | MAPK1 | NM_138957; NM_002745 | TSS1500 | Island |
| cg01216607 | 0.00001 | 0.04888 | 0.13731 | 0.11167 | 0.02564 | ZNHIT1; PLOD3 | NM_006349; NM_001084; NM_001084 | TSS1500; 1st Exon; 5′UTR | Island |
| cg01525244 | 0.00000 | 0.00830 | 0.22203 | 0.17144 | 0.05059 | CBX7 | NM_175709 | TSS200 | N_Shore |
| cg01801101 | 0.00000 | 0.02176 | 0.31191 | 0.27460 | 0.03730 | AMZ1 | NM_133463 | 5′UTR | N_Shore |
| cg02432888 | 0.00001 | 0.03410 | 0.92622 | 0.93604 | −0.00982 | SMARCA4 | NM_001128845; NM_001128844; NM_001128848; NM_001128846; NM_003072; NM_001128849; NM_001128847 | 1st Exon; Body | N_Shelf |
| cg02581963 | 0.00000 | 0.00977 | 0.09723 | 0.06908 | 0.02816 | C10orf75 | NR_026762 | TSS200 | Island |
| cg03027241 | 0.00000 | 0.01712 | 0.35425 | 0.42982 | −0.07557 | KCNG1 | NM_002237 | 3′UTR | Island |
| cg03069383 | 0.00001 | 0.04806 | 0.22846 | 0.20088 | 0.02758 | RDH14 | NM_020905 | 1st Exon | Island |
| cg03074984 | 0.00001 | 0.04262 | 0.22030 | 0.19083 | 0.02947 | RPS6KA4 | NM_003942; NM_001006944 | TSS200 | Island |
| cg03511638 | 0.00000 | 0.02698 | 0.21013 | 0.19248 | 0.01765 | FBXL15 | NM_024326; NM_024326 | 1st Exon; 5′UTR | Island |
| cg03956053 | 0.00000 | 0.00468 | 0.10087 | 0.06957 | 0.03130 | Island | |||
| cg03992938 | 0.00000 | 0.02085 | 0.20399 | 0.18780 | 0.01619 | CCDC13 | NM_144719; NM_144719 | 1st Exon; 5′UTR | Island |
| cg04396550 | 0.00000 | 0.00000 | 0.03999 | 0.02558 | 0.01440 | KCNQ3 | NM_004519 | TSS1500 | Island |
| cg04551440 | 0.00000 | 0.02375 | 0.06975 | 0.05204 | 0.01771 | KATNAL1 | NM_001014380; NM_032116 | TSS200; 5′UTR | Island |
| cg04672769 | 0.00000 | 0.01712 | 0.10358 | 0.08340 | 0.02017 | HARS | NM_002109; NM_012208; NM_002109 | 5′UTR; TSS200; 1stExon | Island |
| cg04699668 | 0.00000 | 0.02654 | 0.78765 | 0.83452 | −0.04687 | N_Shore | |||
| cg04781764 | 0.00000 | 0.01704 | 0.86144 | 0.88530 | −0.02387 | WDR51B | NM_172240 | Body | |
| cg04787602 | 0.00000 | 0.02085 | 0.16300 | 0.14423 | 0.01876 | C1orf183; C1orf183 | NM_198926; NM_019099 | Body; TSS1500 | Island |
| cg04851352 | 0.00001 | 0.04156 | 0.32402 | 0.30766 | 0.01637 | Island | |||
| cg04981696 | 0.00000 | 0.01712 | 0.55926 | 0.49197 | 0.06730 | ABCC1 | NM_019862; NM_019898; NM_019899; NM_004996; NM_019900 | Body | S_Shore |
| cg05020775 | 0.00001 | 0.03145 | 0.11804 | 0.09411 | 0.02393 | SNPH | NM_014723 | TSS200 | Island |
| cg05102190 | 0.00000 | 0.01712 | 0.30075 | 0.26154 | 0.03922 | ZYX | NM_003461; NM_001010972 | TSS200 | Island |
| cg05131957 | 0.00000 | 0.02625 | 0.08817 | 0.06755 | 0.02062 | CRLS1; CRLS1 | NM_019095; NM_019095; NM_001127458 | 1st Exon; 5′UTR; TSS1500 | Island |
| cg05209527 | 0.00001 | 0.03018 | 0.20213 | 0.15172 | 0.05042 | SLC5A6 | NR_028323; NM_080592; NM_021095; NM_016085; NM_001170795 | TSS1500; Body; 5′UTR | S_Shore |
| cg05377161 | 0.00001 | 0.04888 | 0.11639 | 0.09404 | 0.02235 | Island | |||
| cg05629721 | 0.00000 | 0.02654 | 0.29331 | 0.24457 | 0.04875 | PSMB8 | NM_004159; NM_148919; NM_004159 | 5′UTR; TSS1500; 1st Exon | S_Shore |
| cg05977109 | 0.00000 | 0.02085 | 0.09199 | 0.06838 | 0.02361 | SGMS1 | NM_147156 | 5′UTR | Island |
| cg06276429 | 0.00001 | 0.04156 | 0.21157 | 0.17132 | 0.04025 | SLC39A7; RXRB | NM_006979; NM_021976; NM_001077516 | TSS1500; Body | N_Shore |
| cg07067659 | 0.00001 | 0.03187 | 0.03402 | 0.02441 | 0.00961 | SLC7A5 | NM_003486 | 1st Exon | Island |
| cg07112456 | 0.00001 | 0.03536 | 0.93287 | 0.91243 | 0.02044 | LRWD1 | NM_152892 | Body | S_Shelf |
| cg07953400 | 0.00001 | 0.02968 | 0.05508 | 0.04526 | 0.00982 | PIGQ | NM_004204; NM_148920 | TSS1500 | N_Shore |
| cg07956264 | 0.00000 | 0.00228 | 0.06267 | 0.04264 | 0.02003 | GPATCH3 | NM_022078 | 1st Exon | Island |
| cg08180934 | 0.00000 | 0.02625 | 0.05768 | 0.04568 | 0.01200 | STRAP | NM_007178 | TSS200 | Island |
| cg08276889 | 0.00000 | 0.02375 | 0.03778 | 0.02814 | 0.00964 | LOC100133985 | NR_024444 | Body | Island |
| cg08730728 | 0.00001 | 0.04156 | 0.10524 | 0.07919 | 0.02606 | Island | |||
| cg09090048 | 0.00001 | 0.03018 | 0.21230 | 0.18139 | 0.03091 | VPS26B; NCAPD3 | NM_052875; NM_015261 | TSS1500; Body | Island |
| cg09267087 | 0.00001 | 0.04156 | 0.67624 | 0.64183 | 0.03441 | ||||
| cg09367046 | 0.00001 | 0.04262 | 0.07982 | 0.05797 | 0.02184 | ANGEL1 | NM_015305 | TSS200 | Island |
| cg09457469 | 0.00000 | 0.01698 | 0.06248 | 0.04671 | 0.01577 | YBX2 | NM_015982 | Body | Island |
| cg09826692 | 0.00000 | 0.02375 | 0.69472 | 0.71745 | −0.02273 | Island | |||
| cg10059171 | 0.00001 | 0.03187 | 0.07502 | 0.05829 | 0.01674 | GPR89B | NM_016334; NM_016334 | 5′UTR; 1st Exon | Island |
| cg10178228 | 0.00000 | 0.00820 | 0.17082 | 0.11116 | 0.05966 | FRMD4B | NM_015123 | TSS200 | S_Shore |
| cg10369688 | 0.00001 | 0.03018 | 0.15684 | 0.13906 | 0.01778 | ZFP36 | NM_003407 | Body | Island |
| cg10381071 | 0.00000 | 0.01712 | 0.15437 | 0.20650 | −0.05213 | TLE3 | NM_020908; NM_001105192; NM_005078 | TSS1500 | Island |
| cg10576516 | 0.00000 | 0.00019 | 0.05003 | 0.03414 | 0.01589 | RECQL5; SAP30BP | NM_001003716; NM_013260; NM_001003715; NM_013260; NM_004259 | TSS200; 1st Exon; 5′UTR | Island |
| cg10965669 | 0.00001 | 0.02931 | 0.80870 | 0.82408 | −0.01538 | AXIN2 | NM_004655 | Body | Island |
| cg11319362 | 0.00001 | 0.04251 | 0.08666 | 0.06828 | 0.01838 | ARL6IP5 | NM_006407; NM_006407 | 1st Exon; 5′UTR | Island |
| cg11542063 | 0.00000 | 0.02625 | 0.05513 | 0.03884 | 0.01629 | NFE2L2 | NM_006164; NM_006164; NM_001145413; NM_001145412 | 5′UTR; 1st Exon; TSS1500 | Island |
| cg11866422 | 0.00000 | 0.02654 | 0.06337 | 0.05160 | 0.01177 | Island | |||
| cg12289509 | 0.00001 | 0.04442 | 0.12657 | 0.11630 | 0.01027 | TUBE1; C6orf225 | NM_016262; NM_001033564 | Body; TSS200 | Island |
| cg12362980 | 0.00000 | 0.00307 | 0.88730 | 0.91537 | −0.02807 | Island | |||
| cg12407666 | 0.00000 | 0.02901 | 0.12378 | 0.10250 | 0.02128 | RIC8B | NM_018157 | TSS1500 | Island |
| cg12810189 | 0.00001 | 0.03920 | 0.04387 | 0.03696 | 0.00691 | BCAP29 | NR_027830; NM_018844; NM_018844; NM_001008405 | Body; 1st Exon; 5′UTR; TSS1500 | Island |
| cg12850793 | 0.00000 | 0.02321 | 0.15979 | 0.14310 | 0.01669 | DENND5A | NM_015213 | TSS200 | Island |
| cg13110034 | 0.00001 | 0.03187 | 0.07293 | 0.06148 | 0.01145 | ANKRD34A; POLR3GL | NM_001039888; NM_032305 | TSS1500; 5′UTR | Island |
| cg13199615 | 0.00001 | 0.03018 | 0.23755 | 0.21115 | 0.02640 | KRTCAP2; TRIM46 | NM_173852; NM_025058 | TSS1500; Body | N_Shore |
| cg13398864 | 0.00000 | 0.02433 | 0.11061 | 0.08598 | 0.02463 | SEC22A | NM_012430 | TSS200 | N_Shore |
| cg13485756 | 0.00000 | 0.02698 | 0.09370 | 0.08224 | 0.01146 | RB1 | NM_000321 | TSS200 | Island |
| cg14022530 | 0.00000 | 0.02698 | 0.07371 | 0.05385 | 0.01986 | SASS6; CCDC76 | NM_194292; NM_019083 | TSS200 | Island |
| cg14214745 | 0.00000 | 0.01698 | 0.03114 | 0.02396 | 0.00718 | CRELD1 | NM_001077415; NM_001031717; NM_015513; NM_015513; NM_001077415; NM_001031717 | 1st Exon; 5′UTR | Island |
| cg14247318 | 0.00001 | 0.03018 | 0.06991 | 0.05126 | 0.01865 | S_Shore | |||
| cg15043926 | 0.00000 | 0.02698 | 0.28089 | 0.26430 | 0.01659 | STIM2 | NM_001169117; NM_020860; NM_001169118 | Body | Island |
| cg15226170 | 0.00000 | 0.02879 | 0.37491 | 0.31659 | 0.05832 | PMM1 | NM_002676 | TSS1500 | S_Shore |
| cg15324256 | 0.00000 | 0.02625 | 0.05617 | 0.04062 | 0.01555 | QTRTD1; KIAA1407 | NM_024638; NM_020817 | TSS1500; 1st Exon | Island |
| cg15324448 | 0.00000 | 0.02625 | 0.10020 | 0.08001 | 0.02019 | ZNF643 | NM_023070 | TSS200 | Island |
| cg15536552 | 0.07584 | 0.04796 | 0.20583 | 0.34740 | −0.01416 | ACSL4 | NM_022977; NM_004458 | 5′UTR; 5′UTR | N_Shore |
| cg15572086 | 0.00000 | 0.01698 | 0.06120 | 0.04806 | 0.01314 | C1orf203 | NR_027645; NR_024126; NR_024124; NR_027646; NR_024125 | TSS1500 | Island |
| cg15653194 | 0.00000 | 0.00394 | 0.07660 | 0.05163 | 0.02496 | LFNG | NM_001166355; NM_002304; NM_001040168; NM_001040167 | Body; TSS200 | Island |
| cg16007711 | 0.00000 | 0.01712 | 0.11104 | 0.08414 | 0.02689 | RHOBTB2 | NM_001160036; NM_001160037; NM_015178 | Body; 5′UTR | S_Shore |
| cg16306148 | 0.00001 | 0.03359 | 0.01234 | 0.00608 | 0.00626 | YBX1 | NM_004559 | TSS1500 | Island |
| cg16357287 | 0.00000 | 0.00228 | 0.03588 | 0.02229 | 0.01360 | SEH1L; SEH1L | NM_001013437; NM_031216 | TSS1500 | N_Shore |
| cg16398128 | 0.00000 | 0.00000 | 0.04360 | 0.02550 | 0.01810 | ZNF622 | NM_033414; NM_033414 | 5′UTR; 1st Exon | Island |
| cg16416718 | 0.00000 | 0.02879 | 0.16998 | 0.15554 | 0.01445 | CAMTA1 | NM_015215 | TSS1500 | Island |
| cg16743070 | 0.00000 | 0.01721 | 0.04222 | 0.02640 | 0.01582 | MYST3 | NM_001099413; NM_001099412; NM_006766 | 5′UTR | Island |
| cg16803522 | 0.00000 | 0.01441 | 0.03705 | 0.02603 | 0.01102 | RASGRP1 | NM_001128602; NM_005739 | TSS1500 | Island |
| cg17074213 | 0.00001 | 0.02901 | 0.20986 | 0.15861 | 0.05125 | TGFBR3 | NM_003243; NM_003243 | 1st Exon; 5′UTR | Island |
| cg17162475 | 0.00000 | 0.02375 | 0.13817 | 0.12031 | 0.01786 | C6orf150 | NM_138441 | TSS200 | Island |
| cg17168242 | 0.00000 | 0.01599 | 0.09273 | 0.08238 | 0.01035 | OTUD7B | NM_020205 | TSS200 | Island |
| cg17176517 | 0.00001 | 0.04039 | 0.05653 | 0.04319 | 0.01334 | SNX4 | NM_003794; NM_003794 | 5′UTR; 1st Exon | Island |
| cg17427781 | 0.00001 | 0.04227 | 0.08943 | 0.07059 | 0.01884 | DDX20; C1orf183 | NM_007204; NM_198926 | TSS200; Body | Island |
| cg18676790 | 0.00001 | 0.03018 | 0.27930 | 0.34935 | −0.07005 | ||||
| cg18848688 | 0.00001 | 0.02968 | 0.14296 | 0.32549 | −0.18253 | LIFR | NM_001127671; NM_002310 | TSS1500; 5′UTR | Island |
| cg19050851 | 0.00000 | 0.02690 | 0.03973 | 0.02876 | 0.01097 | ARSB | NM_000046; NM_198709 | Body; Body | Island |
| cg19137662 | 0.00000 | 0.01441 | 0.04705 | 0.03249 | 0.01455 | NOP56 | NM_006392; NR_031699; NR_027700; NR_003078 | Body; TSS200; TSS1500 | Island |
| cg19362196 | 0.00000 | 0.02625 | 0.70650 | 0.76251 | −0.05601 | STMN1 | NM_005563; NM_203399; NM_203401; NM_001145454 | TSS1500 | Island |
| cg19520115 | 0.00000 | 0.00160 | 0.12095 | 0.10488 | 0.01607 | CAPZB | NM_004930 | Body | Island |
| cg19634213 | 0.00000 | 0.01712 | 0.05716 | 0.04074 | 0.01643 | PTEN; KILLIN | NM_000314; NM_001126049 | TSS1500; 1st Exon | Island |
| cg19693031 | 0.00001 | 0.03187 | 0.80756 | 0.85146 | −0.04390 | TXNIP | NM_006472 | 3′UTR | |
| cg19878987 | 0.00000 | 0.02280 | 0.10362 | 0.08020 | 0.02342 | LDHB | NM_002300 | TSS1500 | S_Shore |
| cg20656751 | 0.00000 | 0.02625 | 0.51357 | 0.47261 | 0.04096 | NAT8L | NM_178557 | 1stExon | Island |
| cg21012729 | 0.00001 | 0.03763 | 0.08208 | 0.06527 | 0.01681 | NIN | NM_182946; NM_020921; NM_182944 | 5′UTR | Island |
| cg21373806 | 0.00001 | 0.04156 | 0.83546 | 0.86386 | −0.02840 | BAHCC1 | NM_001080519 | Body | N_Shore |
| cg21786114 | 0.00001 | 0.03187 | 0.51357 | 0.46076 | 0.05281 | EHMT2 | NM_006709; NM_025256 | TSS1500 | N_Shore |
| cg22185268 | 0.00000 | 0.00217 | 0.02871 | 0.02008 | 0.00864 | COMMD4 | NM_017828 | TSS200 | Island |
| cg22721468 | 0.00000 | 0.00228 | 0.06494 | 0.04424 | 0.02070 | SH3BP5L | NM_030645 | TSS1500 | Island |
| cg22746421 | 0.00000 | 0.01712 | 0.87645 | 0.85266 | 0.02379 | ||||
| cg22902478 | 0.00001 | 0.04156 | 0.10027 | 0.08525 | 0.01502 | LOC100130987 | NR_024469 | TSS200 | Island |
| cg23224405 | 0.00000 | 0.00011 | 0.06783 | 0.04502 | 0.02281 | DUSP16 | NM_030640; NM_030640 | 1st Exon; 5′UTR | Island |
| cg23348158 | 0.00000 | 0.01712 | 0.09342 | 0.06174 | 0.03168 | FUZ | NM_025129 | TSS200 | S_Shore |
| cg23512165 | 0.00000 | 0.02085 | 0.02886 | 0.02041 | 0.00845 | MTMR4 | NM_004687; NM_004687 | 1st Exon; 5′UTR | Island |
| cg24108286 | 0.00001 | 0.03145 | 0.25285 | 0.21178 | 0.04107 | TFDP1 | NR_026580; NM_007111 | TSS1500 | |
| cg24689754 | 0.00000 | 0.02433 | 0.03045 | 0.02020 | 0.01026 | C19orf62 | NM_001033549; NM_001033549; NM_014173; NM_014173 | 5′UTR; 1st Exon | |
| cg24728479 | 0.00001 | 0.03187 | 0.19258 | 0.17546 | 0.01712 | ZNF252; C8orf77 | NR_023392; NR_026974 | TSS1500; Body | Island |
| cg25053907 | 0.00001 | 0.02968 | 0.06377 | 0.05198 | 0.01179 | ZNF721; PIGG | NM_133474; NM_017733; NM_001127178; NM_133474 | 5′UTR; TSS200; 1st Exon | Island |
| cg25295726 | 0.00000 | 0.01101 | 0.18162 | 0.16283 | 0.01879 | FUT11 | NM_173540 | TSS200 | Island |
| cg25678532 | 0.00000 | 0.02625 | 0.05138 | 0.03889 | 0.01249 | RBBP8 | NM_203291; NM_203292; NM_002894 | TSS1500; TSS200 | Island |
| cg25818813 | 0.00000 | 0.02014 | 0.06671 | 0.05009 | 0.01661 | MERTK | NM_006343 | Body | Island |
| cg25856120 | 0.00001 | 0.04680 | 0.11157 | 0.08244 | 0.02914 | ATP5G1 | NM_005175; NM_005175; NM_001002027 | 1st Exon; 5′UTR | S_Shore |
| cg25989057 | 0.00001 | 0.02942 | 0.03813 | 0.02660 | 0.01154 | AIP | NM_003977 | TSS200 | Island |
| cg26309655 | 0.00001 | 0.04156 | 0.17136 | 0.14822 | 0.02314 | TARS2 | NM_025150 | TSS200 | |
| cg26462136 | 0.00001 | 0.03647 | 0.08411 | 0.06628 | 0.01783 | ATXN7L3 | NM_001098833; NM_020218 | TSS1500 | Island |
| cg26791384 | 0.00001 | 0.04156 | 0.25191 | 0.21622 | 0.03569 | SYCE1L | NM_001129979 | Body | Island |
| cg26824705 | 0.00001 | 0.04888 | 0.08142 | 0.06402 | 0.01740 | MUL1 | NM_024544 | TSS200 | Island |
| cg27164612 | 0.00000 | 0.02654 | 0.01342 | 0.00813 | 0.00529 | ||||
| cg27612695 | 0.00000 | 0.02625 | 0.18852 | 0.15615 | 0.03238 | SUZ12P | NR_024187 | Body | S_Shore |