Table 3.

Comparison of the performance of each test for differentiating NASH versus simple hepatic steatosis.

Test	AUC (95%CI)	Sig	Cut-off	Sens (%)	Spec (%)	PPV (%)	NPV (%)	Z-score	P-value
CK18M65	0.733 (0.546–0.921)	0.027	756.35	73.3	75.0	78.6	76.5
ACSL4	0.689 (0.556–0.821)	0.009	0.123	62.9	57.1	64.9	78.6	1.258	0.20
CTP1A	0.745 (0.581–0.909)	0.013	0.151	70.6	72.2	70.6	72.2	0.08	0.93
CRLS1	0.742 (0.578–0.906)	0.015	0.071	88.9	52.9	67.7	81.8	0.31	0.75
SIGIRR	0.882 (0.758–0.999)	0.001	0.787	70.6	99	92.3	77.3	1.12	0.26
SSBP1	0.817 (0.676–0.958)	0.001	0.04	61.1	94.1	91.7	69.6	0.32	0.75
ZNF622	0.735 (0.567–0.903)	0.017	0.046	50.0	94.1	92.3	61.5	0.08	0.93

AUROC – area under the receiver operating characteristic curve; Sens – sensitivity; Spec – specificity; PPV – positive predictive value; NPV – negative predictive value.