Table 5.
Diagnostic value of anti-dsDNA isotypes, anti-C1q antibody, and low C3 and/or C4 for SLE.
| Sensitivity | Specificity | PPV | NPV | OR (95% CI) | |
|---|---|---|---|---|---|
| Anti-dsDNA IgG | 75% | 93% | 88% | 84% | 37.667 (16.270–87.204) |
| Anti-dsDNA IgM | 45% | 97% | 92% | 69% | 23.731 (8.102–69.512) |
| Anti-dsDNA IgA | 33% | 97% | 89% | 65% | 14.625 (4.951–43.203) |
| Anti-C1q | 49% | 92% | 58% | 83% | 10.679 (4.917–23.193) |
| Low C3 and/or C4 | 81% | 59% | 62% | 79% | 6.097 (2.891–12.858) |
SLE: systemic lupus erythematosus; PPV: positive predictive value; NPV: negative predictive value; OR: odds ratio; CI: confidence interval.