Table 2.
GBA-related phenotypes updated to our previous meta-analysis.
| Phenotypes | Number of articles (total/updated) | Total number of GBA + PD | Total number of GBA − PD | OR or MD (95% CI) updated | p value | Previous OR or MD (95% CI) |
|---|---|---|---|---|---|---|
| Family history∗ a | 11/1 | 558 | 9330 | 1.65 (1.34, 2.02) | <0.00001 | 1.5 (1.18, 1.91) |
| AAO∗ b | 17/4 | 622 | 11079 | −3.61 (−5.04, −2.17) | <0.00001 | −3.10 (−4.88, −1.32) |
| UPDRS-III∗ b | 9/4 | 335 | 6100 | 2.17 (0.72, 3.62) | 0.003 | 1.61 (−0.65, 3.87) |
| H-Y∗ b | 11/3 | 275 | 3863 | 0.18 (0.00, 0.35) | 0.05 | 0.06 (−0.06, 0.17) |
| Dementia∗ a | 8/2 | 224 | 2696 | 2.44 (1.79, 3.33) | <0.00001 | 3.21 (1.97, 5.24) |
| Depression#a | 5 | 196 | 2825 | 1.47 (1.02, 2.13) | 0.04 | — |
| Orthostatic hypotension#a | 4 | 138 | 1913 | 1.24 (0.79, 1.94) | 0.35 | — |
| Motor fluctuation#a | 3 | 195 | 2894 | 0.9 (0.66, 1.24) | 0.53 | — |
| Wearing-off#a | 3 | 88 | 1226 | 1.68 (1.05, 2.69) | 0.03 | — |
| Freezing#a | 3 | 128 | 1688 | 1.14 (0.74, 1.77) | 0.55 | — |
Abbreviations: ∗phenotypes updated new publications; #phenotypes newly analyzed. PD, Parkinson's disease; GBA + PD, PD with GBA mutations; GBA - PD, PD without GBA mutations; AAO, age at onset; UPSRS-III, the Part III of Unified Parkinson Disease Rating Scale; OR, odds ratio; MD, mean deviation; CI, confidence interval. Bold OR or MD, 95% CI, and p values reflected statistically significance results; a, dichotomous variables reflected by OR (95% CI); b, continuous outcomes reflected by MD (95% CI).