Table 2.
Clinical characteristics of cirrhosis patients admitted with HN subdivided by hyponatremia severity.
| Total N = 518 |
[Na+], mmol/L | |||
|---|---|---|---|---|
| <120 n = 106 |
≥120–≤125 n = 202 |
>125–≤130 n = 210 |
||
| Median age, y | 56 | 54 | 56 | 57 |
| Male/female, n | 345/173 | 73/33 | 130/72 | 142/68 |
| BUN, mg/dL | 20.0 (19.0) | 18.0 (20.5) | 21.0 (20.0) | 19.0 (17.0) |
| Cr, mg/dL | 1.0 (0.6) | 1.0 (0.7) | 1.1 (0.7) | 1.0 (0.6) |
| BUN:Cr ratio | 18.9 (10.4) | 19.0 (12.0) | 19.8 (11.6) | 18.0 (9.1) |
| Alb, g/dL | 2.5 (0.8) | 2.6 (1.1) | 2.5 (0.8) | 2.4 (0.6) |
| Tbili, µmol/L | 4.3 (7.4) | 4.3 (7.2) | 4.5 (6.9) | 4.3 (7.6) |
| INR, s | 1.7 (0.6) | 1.6 (0.5) | 1.7 (0.7) | 1.7 (0.7) |
| Severe ascites, n (%) | 284 (55) | 53 (50) | 124 (61) | 107 (51) |
| Severe HE, n (%)a | 116 (22) | 30 (28) | 51 (25) | 35 (17) |
| C-P score | 11.0 (3.0) | 10.5 (3.0) | 11.0 (3.0) | 10.0 (3.0) |
| MELD score | 20.2 (9.7) | 18.7 (9.0) | 20.8 (8.0) | 20.2 (10.4) |
| MELD-Na score | 27.3 (6.3) | 26.7 (5.6) | 28.0 (5.0) | 26.3 (7.6) |
a P < 0.01.
Values for blood urea nitrogen (BUN), creatinine (Cr), BUN:Cr ratio, albumin (Alb), total bilirubin (Tbili), international normalized ratio (INR), and Child-Pugh (CP), Model for End-Stage Liver Disease (MELD), and MELD-NA scores are median (interquartile range). HE, hepatic encephalopathy; HN, hyponatremia.