Table 3.
Patients with [Na+] ≥5 mmol/L in response to initial and secondary therapya.
| Day 2 Response |
Day 3 response |
Final response | |
|---|---|---|---|
| Initial therapy, n (%) | |||
| NST | 9 (27) | 11 (33) | 13 (39) |
| FR | 29 (27) | 38 (36) | 42 (39) |
| NS | 54 (45) | 61 (51) | 62 (52) |
| HS | 7 (78) | 7 (78) | 7 (78) |
| TO | 10 (48) | 15 (71) | 17 (81) |
|
| |||
| Secondary therapy, n (%) | |||
| NST | 5 (36) | 5 (36) | 5 (36) |
| FR | 15 (31) | 18 (37) | 18 (37) |
| NS | 9 (29) | 10 (32) | 10 (32) |
| HS | 10 (100) | 10 (100) | 10 (100) |
| TO | 15 (58) | 17 (65) | 18 (68) |
aPatients with initial moderate or severe hyponatremia.
Initial therapy P <0.05 for Day 2 response: no specific therapy (NST) vs hypertonic saline (HS), and fluid restriction (FR) vs HS and isotonic saline (NS); Day 3 response: NST vs HS and tolvaptan (TO); FR vs HS, NS, and TO: final response: NST vs TO, FR vs HS and TO, and NS vs TO.