Figure 7.

(A) HE-stained tissue sections from mice harvested at 28 days after the single injection of pure saline (control) or MnO-PEG-Cy5.5 (35.0 mg Mn/kg), respectively. Tissues were harvested from heart, liver, spleen, lung, kidney and brain. (B) Relative viabilities of NRVMs, H9c2, and CFs incubated with various concentrations of MnO-PEG-Cy5.5 nanoparticles (0–100 µM Mn). Data are expressed as means ± SD of four independent experiments.

Note: Scale bar=100 µm.

Abbreviations: CFs, cardiac fibroblasts; HE, hematoxylin-eosin; NRVMs, neonatal rat ventricular myocytes.