Table 4: acylglycerols and cholesterols levels in kidney and liver of Pdss2kd/kd mice.
Values are represented as fold changes of mutant group (Mut) compared to age-matched controls (WT) under same treatment.
| WT pl 6mo | Mut pl 6mo | WT CoQ 6mo | Mut CoQ 6mo | |
|---|---|---|---|---|
| Kidney | ||||
| mg | 1±0.54 | 1.24±0.48 | 1±0.32 | 0.81±0.26 |
| dg | 1±1.16 | 0.29±0.1 | 1±0.48 | 0.49±0.07** |
| tg | 1±1.05 | 0.27±0.14 | 1±0.66 | 0.18±0.08 |
| Fc | 1±0.41 | 0.85±0.41 | 1±0.26 | 1.43±0.12* |
| Ce | 1±0.75 | 3.4±2.74 | 1±0.55 | 0.94±0.28 |
| Liver | ||||
| mg | 1±0.35 | 1.02±0.58 | 1±0.28 | 1.17±0.3 |
| dg | 1±0.13 | 0.38±0.13** | 1±0.32 | 0.72±0.10 |
| tg | 1±0.21 | 0.44±0.15** | 1±0.59 | 0.55±0.20 |
| fc | 1±0.25 | 1.40±0.15 | 1±0.12 | 0.97±0.17 |
| ce | 1±0.19 | 3.06±1.45* | 1±0.12 | 0.76±0.16 |
WT= wild type; Mut= mutant, mo= month-old; pl= placebo; CoQ= CoQ10; mg = monoacylglycerol, dg = diacylglycerol, tg = triacylglycerol, fc = free cholesterol, ce = cholesterol esters; N= 5 per group. Bold characters = statistical significance
= p<0.05
= p<0.01
= p<0.001 (Mann Whitney test).