Skip to main content
. Author manuscript; available in PMC: 2018 Oct 11.
Published in final edited form as: Ann Neurol. 2018 Jun 8;83(6):1147–1161. doi: 10.1002/ana.25244

Figure 4. LBS effect on gut microbiota function.

Figure 4

PICRUSt was used to infer the functional content of the gut microbiota based on 16S data. A) Fold change of the abundance of KEGG (Kyoto Encyclopaedia of Genes and Genomes) pathways following administration and discontinuation of LBS in healthy controls and multiple sclerosis (MS) patient assessed by Wilcoxon signed rank test with FDR (false discovery rate) <0.05. B) Effect of LBS on stool metabolites concentration in controls and MS patients determined by Wilcoxon signed rank test, *p<0.05; **p<0.01. Spearman’s correlations between microbiota abundances and stool metabolites concentration following LBS supplementation in C–D) healthy controls (HC) and MS patients. Corr Coefficient = Spearman’s correlation coefficient; OTU = Operational taxonomic unit; ADM = Adenosine monophosphate; NR = New Reference.