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. 2018 Sep 7;77(11):1005–1016. doi: 10.1093/jnen/nly080

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© 2018 American Association of Neuropathologists, Inc. All rights reserved.

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FIGURE 1. — α-Synuclein pathology in the basal ganglia, pons, and medulla of cases with SND. All images here and in the subsequent figures showing α-syn immunohistochemistry are combined with pigment-Nissl stain for lipofuscin pigment (aldehyde fuchsin) and basophilic Nissl material (Darrow red). (A) Glial cytoplasmic α-syn inclusions (GCI) in oligodendroglia of the internal capsule (some of the GCI are indicated by arrowheads). (B) Overview of GCI pathology in the internal capsule (CI) and putamen (PUT). (C) Severe GCI pathology in the pons within transverse pontine fibers (TPF) and fibers of the corticospinal tract (PF). (D) GCI in the TPF and PF also showing multiple neuritic inclusions (NRI) within the TPF. (E) GCI in the PF of the medulla. (F) Neuronal cytoplasmic α-syn inclusion (NI) in the inferior olive of the medulla (arrow), surrounded by multiple NRI and the unaffected inferior olive neurons (arrowheads). All scale bars = 50 μm; scale bar in (C) = 500 μm.