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. 2018 Sep 15;13(6):512–521. doi: 10.1097/COH.0000000000000502

FIGURE 1.

FIGURE 1

Definitions of TB-IRIS. Adapted from INSHI definition. TB-IRIS can also occur when ART is reinitiated after stopping ART and when changing from a failing regiment to a new effective ART regimen. ART, antiretroviral therapy. ∗Major criteria for paradoxical TB-IRIS: (i) new/enlarging LN, cold abscess or other focal tissue involvement; (ii) new/worsening radiological features of TB; (iii) new or worsening central nervous system tuberculosis; (iv) new or worsening serositis. Minor criteria for paradoxical TB-IRIS: (i) new/worsening constitutional symptoms; (ii) new/worsening respiratory symptoms; (iii) new/worsening abdominal pain and peritonitis/hepatomegaly/splenomegaly/abdominal adenopathy.