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. 2018 Oct 8;138(15):1537–1550. doi: 10.1161/CIRCULATIONAHA.118.035901

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© 2018 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Changes in intermediate outcomes with canagliflozin compared to placebo in participants with eGFR <45, 45 to <60, 60 to <90, and ≥90 mL/min/1.73 m² at baseline. Represents the mean difference in change from baseline between canagliflozin and placebo from post-baseline to end of follow-up, except for UACR, where it is percent change in the geometric mean of canagliflozin relative to placebo. BP indicates blood pressure; eGFR, estimated glomerular filtration rate; HbA1c, glycohemoglobin; and UACR, urinary albumin/creatinine ratio.