TABLE II.

Testing for Development of Antibiotic Resistance^*

		Minimum Inhibitory Concentration (μg/mL)
	No. of Samples with CFUs After 48-Hr Broth Culture (Tissue/Implant)	CFUs from Tissue/Implant	Original SAP231	Resistance Breakpoint† According to Clinical Guidelines (μg/mL)
Ceftaroline	18 (10/8)	0.5-1	1	>1
Daptomycin	16 (10/6)	0.5	0.5	>1
Doxycycline	16 (10/6)	30	30	>30
Linezolid	12 (10/2)	1-2	2	>4
Ceftaroline-rifampin‡	1 (1/0)	0.5 (ceftaroline), 0.5 (rifampin)	1 (ceftaroline), 0.5 (rifampin)	>1, >0.5

^*After the 6-week antibiotic treatment, tissue homogenates and sonicated implant solutions with positive bacterial growth underwent minimum inhibitory concentration testing according to guidelines for clinical microbiology specimens.

^†Resistance breakpoints were obtained from the European Committee on Antimicrobial Susceptibility Testing, version 6.0, 2016 (http://www.eucast.org/).

^‡The ceftaroline-rifampin group was the only antibiotic-rifampin-combination group that had bacterial growth for resistance testing.