Table 3. Characteristics of APs in hES-iNs in vitro.
N | NF | NS | ||||
---|---|---|---|---|---|---|
4 weeks | 8 weeks | 4 weeks | 8 weeks | 5 weeks | 8 weeks | |
n | 6 | 6 | 7 | 6 | 7 | 7 |
AP threshold (mV) | -24 ± 2 | -30 ± 2 | -29 ± 3 | -29 ± 3 | -32 ± 2 | -26 ± 1* |
AP amplitude (mV) | 51 ± 6 | 76 ± 3* | 59 ± 5 | 69 ± 7 | 83 ± 4 | 73 ± 4 |
AP rise time (ms) | 1.7 ± 0.3 | 0.8 ± 0.0* | 1.5 ± 0.2 | 0.8 ± 0.1* | 0.8 ± 0.1 | 1.1 ± 0.1* |
½AP amp. width (ms) | 1.7 ± 0.4 | 1.0 ± 0.1 | 1.7 ± 0.1 | 1.2 ± 0.2* | 1.1 ± 0.1 | 1.1 ± 0.1 |
AHP (mV) | 23 ± 3 | 20 ± 1 | 18 ± 3 | 24 ± 3 | 30 ± 2 | 33 ± 1 |
* indicates significant difference between 4–5 and 8 weeks.