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. 2018 Oct 10;38(41):8845–8859. doi: 10.1523/JNEUROSCI.1116-18.2018

Figure 2.

Figure 2.

G-CSF enhances reversal learning. A, Timeline and experimental design. Animals were injected with either PBS or G-CSF before each Reversal 1, but not Reversal 2, test session (top). Representative lever-reward and lever-punishment contingencies (bottom; n = 6–8 per group). B, Number of correct trial to total number of trials ratio during acquisition. C, Reversal learning was enhanced by G-CSF treatment. D, Saline injections were given before each session during Reversal 2. Prior G-CSF treatment did not alter performance during Reversal 2. E, Total number of correct responses was not altered by G-CSF treatment. F, Number of incorrect responses was reduced following G-CSF administration in Reversal 1. G, G-CSF administration increased percentage correct response only after the second day of Reversal 1. H, Number of sessions (left) and number of trials to criteria were significantly decreased during Reversal 1 in the G-CSF-treated group. I, G-CSF administration did not affect number of sessions (left) and number of trials to criteria (right) during Reversal 2. *p < 0.05 from G-CSF. All data are presented as mean SEM.