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. 2018 Oct 10;38(41):8860–8873. doi: 10.1523/JNEUROSCI.0860-18.2018

Figure 4.

Figure 4.

Improved neuromuscular transmission in aged mice by Lrp4 expression. A, B, Reduced ratio of 2nd–10th CMAP amplitudes over the first CMAP amplitude at 40 Hz stimulations. A, Representative traces; B, quantitative data; F(2,90) = 62.4, *p < 0.05, **p < 0.01, ***p < 0.001. N = 4 mice per group, two-way ANOVA. C, Frequency-dependent CMAP reduction. Shown were ratios of 10th over first CMAP amplitudes; F(2,45) = 24.1, **p < 0.01, ***p < 0.001; N = 4 mice per group, two-way ANOVA. D–F, Increased mEPP amplitudes of aged mice by Lrp4 expression. D, representative mEPP traces. E, Comparable mEPP frequencies. F, Increased mEPP amplitudes in 24M-Lrp4 mice compared with 24 M mice; F(2,9) = 18.7, ***p = 0.0005, *p = 0.035; N = 4 mice per group, one-way ANOVA.