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. 2018 Oct 10;38(41):8745–8758. doi: 10.1523/JNEUROSCI.0897-18.2018

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Copyright © 2018 Matsumoto et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 9. — TRPV4 activation occurs upstream of MCP-1 release in Müller glial cells and accelerates photoreceptor cell death in RD. Control anti-IgG antibody, neutralizing anti-MCP-1 antibody, or control PBS was injected into the subretinal space when creating retinal detachment for WT and TRPV4KO mice. A, Representative images of TUNEL staining in RD retinal tissues from WT mice (PBS, IgG, or neutralizing anti-MCP-1 antibody). The WT eyes with neutralizing anti-MCP-1 antibody (100 μg/ml) showed significantly less photoreceptor cell death compared with control eyes (PBS or IgG) 24 h after retinal detachments (*p = 0.012611 vs PBS, *p = 0.012851 vs IgG; n = 10). B, Representative images of TUNEL staining in RD retinal tissues from TRPV4KO mice (PBS, IgG, or neutralizing anti-MCP-1 antibody). The TRPV4KO eyes (n = 8) with neutralizing anti-MCP-1 antibody (100 μg/ml) did not show a significant difference in photoreceptor cell death compared with control eyes 24 h after retinal detachments. ONL, Outer nuclear layer; INL, inner nuclear layer.