Table 1.
Summary data for spike and spectral results
| Figure | Metric | P5-P6 | P9-P11 | P13-P14 | P16-P19 | P21-P26 | P42-P60 | ANOVA for age | p value | |
|---|---|---|---|---|---|---|---|---|---|---|
| Multiunit | ||||||||||
| 2A1 | VC | Spikes per second | 0.23 ± 0.08 | 0.95 ± 0.49 | 8.46 ± 1.41 | 10.99 ± 2.11 | 18.01 ± 5.78 | 21.64 ± 7.18 | F(5,30) = 17.3 | =10−7 |
| 2A2 | LGN | Spikes per second | 2.29 ± 0.56 | 6.32 ± 0.94 | 19.06 ± 5.74 | 24.75 ± 5.01 | 25.83 ± 3.3 | 56.27 ± 9.88 | F(5,30) = 30.1 | =10−10 |
| 2B1 | VC | Continuity | 0.02 ± 0.01 | 0.03 ± 0.02 | 0.57 ± 0.07 | 0.7 ± 0.07 | 0.82 ± 0.06 | 0.9 ± 0.03 | F(5,30) = 28.2 | =10−9 |
| 2B2 | LGN | Continuity | 0.14 ± 0.03 | 0.25 ± 0.03 | 0.8 ± 0.06 | 0.95 ± 0.02 | 0.96 ± 0.01 | 1.0 ± 0.0 | F(5,30) = 149 | =10−19 |
| 2C1 | VC | Change during movement | −26.3 ± 5.6%* | −50.3 ± 8.5%* | 35.4 ± 11.9% | 26.8 ± 6.1%* | 24.3 ± 7.6%* | 44.3 ± 19.3%* | F(5,30) = 12.2 | =10−5 |
| 2C2 | LGN | Change during movement | −25.2 ± 6.7%* | −23.6 ± 3.7%* | 87.5 ± 26.9%* | 79.9 ± 15.7%* | 105.6 ± 13.6%* | 83.2 ± 17.7%* | F(5,30) = 13.8 | =10−6 |
| 3C | VC | Spike rate change after LGN silencing | −78.6 ± 3%* | −60.7 ± 7.1%* | −55.5 ± 2.6%* | −58.7 ± 7.3%* | −59.6 ± 7.5%* | F(4,25) = 2.39 | =0.0775 | |
| 3D | VC | Continuity change after LGN silencing | −94.2 ± 1.2%* | −86.1 ± 3.2%* | −75.5 ± 6.2%* | −69.1 ± 3.6%* | −58.7 ± 10.6%* | F(4,25) = 5.51 | =0.0025 | |
| 3E | VC | Change during movement (before LGN silence) | −35.8 ± 9.3%* | 11.5 ± 6.2% | 19.8 ± 4%* | 24.3 ± 7.6%* | 44.3 ± 19.3%* | F(4,25) = 7.74 | =0.0003 | |
| 3E | VC | Change during movement (after LGN silence) | −49.9 ± 10.8%* | −56.7 ± 9.2%* | −47.9 ± 10.4%* | −37 ± 11.1%* | −36.1 ± 6%* | F(4,25) = 0.82 | =0.5252 | |
| 7E | VC | On Latency, ms | 246.7 ± 16.3 | 95.2 ± 4.6 | 55.2 ± 4.4 | 39.8 ± 1.3 | 27.2 ± 2.7 | F(4,25) = 127.6 | =10−15 | |
| 7E | LGN | On Latency, ms | 136.5 ± 15.1 | 67.2 ± 4.3 | 42 ± 3.8 | 29.7 ± 1.1 | 15.8 ± 1 | F(4,25) = 43.2 | =10−10 | |
| 7F | VC | Off Latency, ms | 560.5 ± 46.2 | 146.5 ± 8.7 | 94.3 ± 4.9 | 83.8 ± 5.3 | 82.8 ± 2.1 | F(4,25) = 94.4 | =10−13 | |
| 7F | LGN | Off Latency, ms | 683.2 ± 39.6 | 157.5 ± 10.1 | 115.7 ± 12.1 | 89 ± 7.1 | 85.5 ± 2.8 | F(4,25) = 176.5 | =10−17 | |
| 7G | VC | Duration, ms | 313.8 ± 44.3 | 51.3 ± 7.6 | 39.2 ± 6.2 | 44.1 ± 5.1 | 55.7 ± 4.2 | F(4,25) = 33.8 | =10−9 | |
| 7G | LGN | Duration, ms | 546.7 ± 39.5 | 90.3 ± 11.5 | 73.7 ± 14.3 | 59.3 ± 7.9 | 69.7 ± 3.4 | F(4,25) = 113.9 | =10−14 | |
| 7H | VC | On delay (VC-LGN), ms | 110.2 ± 9.4 | 28 ± 2.9 | 13.2 ± 1.4 | 10.1 ± 1.2 | 11.3 ± 2.2 | F(4,25) = 87.2 | =10−13 | |
| 7I | LGN | Off delay (VC-LGN), ms | 122.7 ± 29 | 11 ± 6.5 | 21.3 ± 9.8 | 5.2 ± 6.5 | 2.7 ± 2.4 | F(4,25) = 12.6 | =10−5 | |
| Single unit | ||||||||||
| 5C | LGN | No. of single units | 11.5 ± 2.7 | 14.5 ± 2 | 32 ± 4.6 | 43 ± 2.9 | 36.8 ± 3.5 | 41.7 ± 3.3 | F(5,30) = 17.6 | =10−7 |
| 5D | LGN | Spikes in SU clusters, % | 54.7 ± 12.3% | 41.7 ± 3.8% | 61 ± 2% | 71.9 ± 6% | 69.4 ± 4.3% | 74.3 ± 3.6% | F(5,30) = 2.48 | =0.054 |
| 5E | LGN | Spike amplitude, μV | 65.8 ± 4.5 | 82 ± 10.4 | 95 ± 3.5 | 114.6 ± 5.7 | 91.6 ± 10.3 | 130.6 ± 6.1 | F(5,30) = 10.0 | =10−4 |
| 5F | LGN | Spike width, ms | 0.74 ± 0.02 | 0.73 ± 0.02 | 0.76 ± 0.01 | 0.72 ± 0.02 | 0.57 ± 0.02 | 0.51 ± 0.01 | F(5,30) = 37.82 | =10−11 |
| 5G1 | LGN | Spikes per second | 0.49 ± 0.04 | 0.9 ± 0.13 | 1.35 ± 0.09 | 1.43 ± 0.12 | 2.13 ± 0.19 | 3.18 ± 0.2 | F(5,30) = 46.1 | =10−12 |
| 5G2 | LGN | Spikes per second | 0.51 ± 0.04 | 0.92 ± 0.07 | 1.33 ± 0.08 | 1.44 ± 0.08 | 2.12 ± 0.12 | 3.18 ± 0.2 | F(5,1701) = 51.5 | =10−47 |
| 5H1 | LGN | Continuity | 0.06 ± 0.01 | 0.08 ± 0.01 | 0.14 ± 0.01 | 0.14 ± 0.01 | 0.23 ± 0.02 | 0.31 ± 0.02 | F(5,30) = 45.6 | =10−12 |
| 5H2 | LGN | Continuity | 0.06 ± 0.01 | 0.08 ± 0.01 | 0.13 ± 0.01 | 0.14 ± 0.01 | 0.23 ± 0.01 | 0.32 ± 0.02 | F(5,1701) = 52.39 | =10−47 |
| 5I1 | LGN | Change during movement | −29.4 ± 5.7%* | −22.2 ± 4.2%* | 61.9 ± 13.7%* | 89.9 ± 14.5%* | 67.3 ± 9.7%* | 48.2 ± 8.8%* | F(5,30) = 24.0 | =10−8 |
| 5I2 | LGN | Change during movement | −28.2 ± 12.2%* | −22.9 ± 6%* | 63.6 ± 4.2%* | 86.6 ± 3.4%* | 64.6 ± 3.7%* | 50.8 ± 4%* | F(5,1701) = 50.74 | =10−46 |
| 6D1 | LGN | Spikes in bursts (movement) | 0.4% ± 0.1% | 0.5% ± 0.3% | 0.7% ± 0.1% | 1% ± 0.1% | 1.2% ± 0.2% | 1.4% ± 0.2% | F(5,30) = 4.48 | =0.0036 |
| 6D2 | LGN | Spikes in bursts (quiescence) | 0.6% ± 0.1% | 0.8% ± 0.3% | 1.3% ± 0.5% | 8.9% ± 0.4% | 8.1% ± 1.4% | 9.2% ± 1.6% | F(5,30) = 22.4 | =10−8 |
| Spectral bands (Permutation test) | ||||||||||
| 2D | VC | Frequencies decreased during movement, Hz | 7.5–8.9 | 8.2–22.9 | 2.1–6.3 | 1.7–11.5 | 2.7–17.7 | 1.4–17.1 | ||
| Frequencies increased during movement, Hz | 16.2–49.6 | 35.2–45.4 | 27.1–58.9 | 41.7–49.6 | ||||||
| 2E | VC | Negative correlation with LGN spike rate, Hz | 1.5–6.3 | 1.5–14.9 | 2.5–8.9 | 1.5–13.7 | ||||
| Positive correlation with LGN spike rate, Hz | 13.7–98.6 | 25.0–98.6 | 25.0–98.6 | 29.60.7–98.6 | ||||||
| 3F | VC | Frequency decreased w/movement, Hz (before silence) | 8.9–22.9 | 1.7–8.9 | 3.8–13.7 | 2.7–17.7 | 1.5–14.9 | |||
| Frequency increased w/movement, Hz (before silence) | 16.2–41.8 | 32.3–45.5 | 27.1–49.6 | 41.8–49.6 | ||||||
| 3G | VC | Frequency decreased w/movement, Hz (after silence) | 1.5–16.2 | 1.5–10.6 | 1.6–3.5 | 1.5–4.9 | 1.9–7.5 | |||
| Frequency increased w/movement, Hz (after silence) | ||||||||||
| 6C | LGN | Interspike interval decreased w/movement, ms | 1–4 | 1–3 | 1–3 | |||||
| Interspike interval increased w/movement, ms | 48–51 | 19–79 | 17–51 | 8–17 | ||||||
*Significantly different from 0.