Table 1. Characteristics of patients diagnosed with pulmonary tuberculosis and their asymptomatic household contacts.
Active TB Disease (n = 17) |
Household Contacts (n = 16) |
P-valuec | |
---|---|---|---|
Age [years; median (IQR)]a | 27 (24–42) | 35 (29–48) | 0.05 |
Male sex, n (%) | 10 (59%) | 6 (38%) | 0.22 |
Tobacco use | 13 (76%) | 6 (38%) | 0.02 |
High grade AFB sputum smeara | 1 (6%) | N/A | N/A |
>100 Colonies on semi-quantitative culture | 7 (41%) | N/A | N/A |
Cavitation on chest radiograph | 2 (12%) | N/A | N/A |
Multidrug-resistant TBb | 3 (18%) | N/A | N/A |
IQR, interquartile range; AFB, acid-fast bacilli; TB, tuberculosis.
a. Sputum smear and culture obtained at study enrollment; high grade smear defined as > 1 AFB per high power field
b. Multidrug resistance was defined as resistance to both isoniazid and rifampin by drug susceptibility testing
c. A Wilcoxon rank sum test was used for comparisons of continuous data and a two-tailed Fisher exact test was used for categorical data