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(A) The single chain variable domains of POM1 and POM2 are joined by a flexible linker to yield the bispecific scPOM-bi, schematic representation. B) Computational molecular dynamics model of scPOM-bi in complex with mPrP; intra-molecular (left and S1 Movie) and inter-molecular (right and S2 Movie) binding modes are shown. They are both structurally accessible to scPOM-bi.
