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. 2018 Aug 6;3(5):e677. doi: 10.1097/PR9.0000000000000677

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Effects of CoPP or CORM-2 treatment on the antiallodynic responses to low doses of pregabalin and gabapentin. Pretreatment with CoPP or CORM-2 significantly enhanced the attenuation of the mechanical antiallodynic effects of (A) pregabalin or (B) gabapentin compared with the control group, which was treated with vehicle (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, 1-way ANOVA followed by the Tukey multiple comparison test, n = 6–7). Bars indicate the mean and SEM. ANOVA, analysis of variance; CoPP, cobalt protoporphyrin IX; CORM-2, tricarbonyldichlororuthenium (II) dimer.