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. 2018 Aug 6;3(5):e677. doi: 10.1097/PR9.0000000000000677

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Reversal of the antinociceptive responses produced by high doses of pregabalin or gabapentin in SNI-affected mice with the administration of the HO-1 inhibitor SnPP. The coadministration of pregabalin or gabapentin with SnPP completely prevented the mechanical antiallodynic effects produced by (A) pregabalin or (B) gabapentin administered alone (*P < 0.05, ****P < 0.0001, 1-way ANOVA followed by the Tukey multiple comparison test, n = 6–7). Bars indicate the mean and SEM. ANOVA, analysis of variance; SnPP, tin protoporphyrin IX; SNI, spared nerve injury.