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. 2018 Aug 6;3(5):e677. doi: 10.1097/PR9.0000000000000677

Figure 5.

Figure 5.

Effects of CoPP and CORM-2 on HO-1, HO-2, α2δ1, and iNOS gene expression in the spinal dorsal horn of mice with SNI. The expression of (A) HO-1 or (C) α2δ1 was significantly increased by CoPP or CORM-2 treatment. The mRNA level of (B) HO-2 or (D) iNOS in the ipsilateral spinal dorsal horn was not altered by CoPP or CORM-2 (*P < 0.05, 1-way ANOVA followed by the Tukey multiple comparison test, n = 4–6). Bars indicate the mean and SEM. ANOVA, analysis of variance; CoPP, cobalt protoporphyrin IX; CORM-2, tricarbonyldichlororuthenium (II) dimer; HO-1, heme oxygenase-1; HO-2, heme oxygenase-2; iNOS, inducible nitric oxide synthase; SNI, spared nerve injury.