Figure 7.

Effects of pregabalin alone or pregabalin combined with SnPP on HO-1, HO-2, α₂δ₁, iNOS, and microglial or astrocytic markers or proinflammatory cytokine gene expression in the spinal dorsal horn of mice with SNI (A–K) (*P < 0.05, **P < 0.01, 1-way ANOVA followed by the Tukey multiple comparison test, n = 4–5). Bars indicate the mean and SEM. ANOVA, analysis of variance; Arg-1, arginase-1; GFAP, glial fibrillary acidic protein; HO-1, heme oxygenase-1; HO-2, heme oxygenase-2; Iba-1, ionized calcium-binding adapter molecule-1; IL-1β, interleukin-1β; iNOS, inducible nitric oxide synthase; SNI, spared nerve injury; TNFα, tumor necrosis factor.