TABLE 2.
RNA sequence analysis of human lung microvascular ECs
| Gene | Reads/kilobase/106 | Gene | Reads/kilobase/106 |
|---|---|---|---|
| CREB1 | 0.651 | TIE1 | 13.806 |
| ATF2 | 0.536 | TEK | 0.992 |
| CREB3 | 7.279 | ANGPT1 | 0.003 |
| ADRA1A | 0.001 | ANGPT2 | 1.136 |
| ADRA1B | 0.034 | ANGPT4 | 0.001 |
| ADRA1D | 0.004 | RAC1 | 6.656 |
| ADRA2A | 0.058 | RAC2 | 3.179 |
| ADRA2B | 0.017 | RAC3 | 3.256 |
| ADRA2C | 0.000 | RHOA | 8.227 |
| ADRB1 | 0.029 | RHOB | 111.569 |
| ADRB2 | 2.764 | RHOC | 61.072 |
| ADRB3 | 0.015 | RHOD | 0.302 |
| ICAM1 | 2.034 | RHOF | 0.213 |
| CDH5 | 19.472 | RHOG | 1.435 |
| PECAM1 | 64.257 | RHOH | 0.001 |
| FLT1 | 0.883 | RAP1A | 0.217 |
| KDR | 9.786 | RAP1B | 2.889 |
| FLT4 | 0.181 | S1PR1 | 32.396 |
| VEGFA | 0.434 | S1PR2 | 0.103 |
| VEGFB | 3.146 | S1PR3 | 1.785 |
| VEGFC | 0.187 | S1PR4 | 0.228 |
| RRAS | 5.414 | S1PR5 | 0.011 |
| TC21 | 0.575 | TGFBI | 2.355 |
| MRAS | 0.088 | TGFB2 | 0.142 |
| NRAS | 13.365 | TGFB3 | 0.081 |
| KRAS | 0.858 | TGFBR1 | 0.398 |
| HRAS | 8.150 | TGFBR2 | 5.635 |
| AKT1 | 5.101 | TGFBR3 | 0.096 |
| AKT2 | 0.325 | SMAD1 | 0.608 |
| AKT3 | 0.255 | SMAD1-AS1 | 0.086 |
| JAG1 | 2.811 | SMAD1-AS2 | 0.047 |
| JAG2 | 1.295 | SMAD2 | 1.148 |
| JAGN1 | 5.149 | SMAD3 | 0.637 |
| DLL1 | 0.1397 | SMAD4 | 1.070 |
| DLL3 | 0.0467 | SMAD5 | 1.648 |
| DLL4 | 1.7064 | SMAD5-AS1 | 0.104 |
| NOTCH1 | 1.543 | SMAD6 | 0.042 |
| NOTCH2 | 0.361 | SMAD7 | 0.086 |
| NOTCH2NL | 0.137 | SMAD9 | 0.100 |
| NOTCH3 | 0.006 | ACVRL1 | 15.708 |
| NOTCH4 | 7.280 | TGFBR1 | 0.398 |
RNA-Seq analysis was conducted to compare relative expression levels of angiogenesis or vascular stability-related genes and other genes in ECs.