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. Author manuscript; available in PMC: 2019 Oct 10.
Published in final edited form as: Neuron. 2018 Sep 27;100(1):150–166.e4. doi: 10.1016/j.neuron.2018.09.007

Figure 5. Neurexin and Frizzled are parallel synapse assembly pathways.

Figure 5.

A-D. Dorsal axons of worms expressing the active zone marker CLA-1::GFP (wyIs685). Each panel is a compilation of the axons of 10 worms of the indicated genotype, aligned to the point at which the axon first reaches the dorsal cord (indicated by black arrowhead above panel A). Synapse number is normal in Fr/lin-17(n3091) mutants (B), but is markedly reduced in nrx-1(null);Fz/lin-17(n3091) double mutants (C). Presynaptic expression of Fz/LIN-17 (wyEx9376) can rescue synapse development (D). E. Quantification of synapse number (as defined by CLA-1 puncta number). Sample size (number of worms) indicated on bars. Statistical significance (ANOVA with Sidak correction) is compared as indicated.