TABLE 2.

TAG-SNP GENOTYPE FREQUENCIES IN THE SEVERE TBI POPULATION

SNP Details	Variable Measured	Homozygous Wild-Type	Heterozygous	Homozygous Variant	p-value (ANOVA /Fisher)
rs7105832 (Intron 3) Wild-type A Variant C	SNP Frequency in sTBI population (%)	160 (42.9%)	171 (45.8%)	42 (11.3%)
	• Average ICP, Mean (SD)	10 ± 3 mmHg	10 ± 4 mmHg	13 ± 7.5 mmHg	0.003*
	• Peak ICP, Mean (SD)	28.8 ± 17 mmHg	24.2 ± 10.3 mmHg	31.9 ± 19 mmHg	0.020*
	• Acute CT Edema, Y frequency (%)	68/150 (45.3%)	57/155 (36.8%)	25/40 (62.5%)	0.012*
	• Favorable GOS ≥ 4, Y frequency (%)	53/160 (33.1%)	53/171 (31%)	9/42 (21.4%)	0.358
rs2237982 (Intron 10) Wild-type C Variant T	SNP Frequency in sTBI population (%)	133 (33.17%)	192 (47.88%)	76 (18.95%)
	• Average ICP, Mean (SD)	9.9 ± 2.9 mmHg	10.3 ± 3.8 mmHg	12.4 ± 7.8 mmHg	0.0107*
	• Peak ICP, Mean (SD)	29.2 ± 17.5 mmHg	24.8 ± 11 mmHg	31.6 ± 18.3 mmHg	0.0190*
	• Acute CT Edema, Y frequency (%)	54/120 (45%)	66/176 (37.5%)	38/67 (56.7%)	0.0204*
	• Favorable GOS ≥ 4, Y frequency (%)	43/133 (32.3%)	66/192 (34.4%)	13/76 (17.1%)	0.015*
rs11024286 (Intron 10) Wild-type G Variant A	SNP Frequency in sTBI population (%)	187 (47.10%)	160 (40.3%)	50 (12.59%)
	• Average ICP, Mean (SD)	11.2 ± 5.9 mmHg	10.2 ± 3.7 mmHg	9.8 ± 2.9 mmHg	0.2207
	• Peak ICP, Mean (SD)	28.6 ± 15.2 mmHg	26.9 ± 14.7 mmHg	26 ± 17.5 mmHg	0.6108
	• Acute CT Edema, Y frequency (%)	74/169 (43.8%)	64/147 (43.6%)	19/44 (43.2%)	1.0
	• Favorable GOS ≥ 4, Y frequency (%)	44/187 (23.5%)	60/160 (37.5%)	16/50 (32%)	0.017*
rs4148622 (Intron 15) Wild-type G Variant A	SNP Frequency in sTBI population (%)	224 (55.86%)	141 (35.16%)	36 (8.98%)
	• Average ICP, Mean (SD)	10.6 ± 4.6 mmHg	10.8 ± 5.5 mmHg	9.9 ± 3.5 mmHg	0.7402
	• Peak ICP, Mean (SD)	26.7 ± 13.1 mmHg	29.4 ± 19.1 mmHg	24.7 ± 9.7 mmHg	0.3162
	• Acute CT Edema, Y frequency (%)	90/206 (43.7%)	59/129 (45.8%)	10/28 (35.7%)	0.636
	• Favorable GOS ≥ 4, Y frequency (%)	70/224 (31.3%)	35/141 (24.82%)	18/36 (50%)	0.016*