Table 3. Parsimonious, Sex-Specific and Full Models for Regional Fractional Anisotropy (FA) in the Uncinate Fasciculus (UF).

The association between average maternal Interleukin-6 (IL-6) concentration across pregnancy and FA in the central UF ROI remained bi-laterally significant (p<0.05) after adjusting for confounding variables. Sex-specific effects of maternal gestational IL-6 concentration were not significant. None of the confounding factors in the full model were significantly (p<0.05) associated with FA suggesting the parsimonious model as the most appropriate choice.

Dependent Var.	Fiber Tract	Independent Var.	r- squared	p- statistic
Parsimonious	L UF	Gestational Age	6.7%	0.016	*
FA (N=86)		Postnatal Age	14.2%	<0.001	***
		Avg. Maternal IL-6	10.1%	0.003	**
	R UF	Gestational Age	6.3%	0.017	*
		Postnatal Age	8.2%	0.009	**
		Avg. Maternal IL-6	14.3%	0.001	***
Sex-Specific	L UF	Gestational Age	5.8%	0.015	*
FA (N=86)		Postnatal Age	11.4%	0.001	**
		Avg. Maternal IL-6	6.7%	0.009	**
		Sex	0.0%	0.953
		Sex x IL-6	0.9%	0.317
	R UF	Gestational Age	5.7%	0.016	*
		Postnatal Age	6.9%	0.008	**
		Avg. Maternal IL-6	10.2%	0.001	**
		Sex	0.8%	0.369
		Sex x IL-6	1.5%	0.214
Full Model	L UF	Gestational Age	4.6%	0.033	*
FA (N=86)		Postnatal Age	10.4%	0.002	**
		Avg. Maternal IL-6	4.9%	0.028	*
		Sex	0.0%	0.457
		Obstetric Risk	1.5%	0.504
		Pre-preg. BMI	0.4%	0.968
		Family Income	0.1%	0.747
		Maternal Smoking	0.0%	0.860
	R UF	Gestational Age	4.6%	0.032	*
		Postnatal Age	7.0%	0.009	**
		Avg. Maternal IL-6	10.1%	0.002	**
		Sex	0.4%	0.462
		Obstetric Risk	1.5%	0.929
		Pre-preg. BMI	0.0%	0.340
		Family Income	0.0%	0.840
		Maternal Smoking	0.9%	0.523